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Protein synthesis and actin polymerization in the rapid effects of 17ß-estradiol on short-term social memory and dendritic spine dynamics in female mice.
Sheppard, Paul A S; Asling, Hayley A; Walczyk-Mooradally, Alicyia; Armstrong, Sabrina E; Elad, Vissy M; Lalonde, Jasmin; Choleris, Elena.
Afiliación
  • Sheppard PAS; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, Canada.
  • Asling HA; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
  • Walczyk-Mooradally A; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
  • Armstrong SE; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, Canada.
  • Elad VM; Department of Human Health and Nutrition Sciences, University of Guelph, Guelph, ON, Canada; Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada.
  • Lalonde J; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
  • Choleris E; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, Canada. Electronic address: echoleri@uoguelph.ca.
Psychoneuroendocrinology ; 128: 105232, 2021 06.
Article en En | MEDLINE | ID: mdl-33892375
Estrogens rapidly facilitate learning and memory, including social recognition - the ability of an animal to recognize another. In ovariectomized female mice, systemic or dorsal hippocampal administration of 17ß-estradiol (E2) facilitates short-term social recognition memory within 40 min. Within the same timeframe, E2 increases dendritic spine density in CA1 dorsal hippocampal neurons of behavioural task-naïve mice and in hippocampal sections. Mechanisms underlying these effects remain unclear. Estrogens rapidly modulate actin cytoskeletal dynamics through actin polymerization and the translation of key synaptic proteins. We first determined doses of actin polymerization inhibitor latrunculin A (LAT) and protein synthesis inhibitor anisomycin (ANI) that would block short-term social recognition memory when infused into the dorsal hippocampus of ovariectomized female mice 15 min prior to testing. The highest doses that did not block social recognition prevented the facilitating effects of E2, whereas DNA transcription inhibitor, actinomycin D, could not block social recognition. As task performance may interfere with E2-facilitated increases in dendritic spine density, dendritic spine density and length were examined in task-performing and task-naïve mice. E2 increased dendritic spine density 15 but not 40 min following treatment, regardless of whether the animal had performed the social recognition task. This effect was blocked by LAT, but not ANI. Thus, both actin polymerization and protein synthesis are necessary for E2 to rapidly facilitate social recognition, whereas actin polymerization, but not protein synthesis, is required for the rapid increase in dendritic spine density brought on by E2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actinas / Espinas Dendríticas / Estradiol / Polimerizacion / Memoria a Corto Plazo Límite: Animals Idioma: En Revista: Psychoneuroendocrinology Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actinas / Espinas Dendríticas / Estradiol / Polimerizacion / Memoria a Corto Plazo Límite: Animals Idioma: En Revista: Psychoneuroendocrinology Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido