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Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells.
Singh, Nathan; Frey, Noelle V; Engels, Boris; Barrett, David M; Shestova, Olga; Ravikumar, Pranali; Cummins, Katherine D; Lee, Yong Gu; Pajarillo, Raymone; Chun, Inkook; Shyu, Amy; Highfill, Steven L; Price, Andrew; Zhao, Linlin; Peng, Liaomin; Granda, Brian; Ramones, Melissa; Lu, Xueqing Maggie; Christian, David A; Perazzelli, Jessica; Lacey, Simon F; Roy, Nathan H; Burkhardt, Janis K; Colomb, Florent; Damra, Mohammad; Abdel-Mohsen, Mohamed; Liu, Ting; Liu, Dongfang; Standley, Daron M; Young, Regina M; Brogdon, Jennifer L; Grupp, Stephan A; June, Carl H; Maude, Shannon L; Gill, Saar; Ruella, Marco.
Afiliación
  • Singh N; Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. nathan.singh@wustl.edu.
  • Frey NV; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. nathan.singh@wustl.edu.
  • Engels B; Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA. nathan.singh@wustl.edu.
  • Barrett DM; Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Shestova O; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Ravikumar P; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Cummins KD; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Lee YG; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Pajarillo R; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Chun I; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Shyu A; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Highfill SL; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Price A; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Zhao L; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Peng L; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Granda B; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Ramones M; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Lu XM; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Christian DA; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Perazzelli J; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Lacey SF; Penn Institute for Biomedical Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Roy NH; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Burkhardt JK; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Colomb F; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Damra M; Translational and Correlative Studies Laboratory, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Abdel-Mohsen M; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Liu T; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Liu D; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
  • Standley DM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Young RM; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
  • Brogdon JL; The Wistar Institute, Philadelphia, PA, USA.
  • Grupp SA; The Wistar Institute, Philadelphia, PA, USA.
  • June CH; The Wistar Institute, Philadelphia, PA, USA.
  • Maude SL; Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
  • Gill S; Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
  • Ruella M; Center for Immunity and Inflammation, Rutgers New Jersey Medical School State University of New Jersey, Newark, NJ, USA.
Nat Med ; 27(5): 842-850, 2021 05.
Article en En | MEDLINE | ID: mdl-33888899
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Inmunoterapia Adoptiva / Lectina 2 Similar a Ig de Unión al Ácido Siálico / Ligando 4-1BB / Leucemia-Linfoma Linfoblástico de Células Precursoras / Receptores Quiméricos de Antígenos Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Inmunoterapia Adoptiva / Lectina 2 Similar a Ig de Unión al Ácido Siálico / Ligando 4-1BB / Leucemia-Linfoma Linfoblástico de Células Precursoras / Receptores Quiméricos de Antígenos Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos