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Replication timing maintains the global epigenetic state in human cells.
Klein, Kyle N; Zhao, Peiyao A; Lyu, Xiaowen; Sasaki, Takayo; Bartlett, Daniel A; Singh, Amar M; Tasan, Ipek; Zhang, Meng; Watts, Lotte P; Hiraga, Shin-Ichiro; Natsume, Toyoaki; Zhou, Xuemeng; Baslan, Timour; Leung, Danny; Kanemaki, Masato T; Donaldson, Anne D; Zhao, Huimin; Dalton, Stephen; Corces, Victor G; Gilbert, David M.
Afiliación
  • Klein KN; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
  • Zhao PA; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
  • Lyu X; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
  • Sasaki T; State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen, China.
  • Bartlett DA; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
  • Singh AM; San Diego Biomedical Research Institute, La Jolla, CA 92121, USA.
  • Tasan I; Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
  • Zhang M; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
  • Watts LP; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Hiraga SI; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Natsume T; Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
  • Zhou X; Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
  • Baslan T; Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Yata 1111, Mishima, Shizuoka 411-8540, Japan.
  • Leung D; Department of Genetics, The Graduate University for Advanced Studies (SOKENDAI), Yata 1111, Mishima, Shizuoka 411-8540, Japan.
  • Kanemaki MT; Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
  • Donaldson AD; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Zhao H; Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
  • Dalton S; Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Yata 1111, Mishima, Shizuoka 411-8540, Japan.
  • Corces VG; Department of Genetics, The Graduate University for Advanced Studies (SOKENDAI), Yata 1111, Mishima, Shizuoka 411-8540, Japan.
  • Gilbert DM; Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Science ; 372(6540): 371-378, 2021 04 23.
Article en En | MEDLINE | ID: mdl-33888635
The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin modifications and three-dimensional genome architecture; however, causal links have not been established, largely because of an inability to manipulate the global RT program. We show that loss of RIF1 causes near-complete elimination of the RT program by increasing heterogeneity between individual cells. RT changes are coupled with widespread alterations in chromatin modifications and genome compartmentalization. Conditional depletion of RIF1 causes replication-dependent disruption of histone modifications and alterations in genome architecture. These effects were magnified with successive cycles of altered RT. These results support models in which the timing of chromatin replication and thus assembly plays a key role in maintaining the global epigenetic state.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión a Telómeros / Momento de Replicación del ADN / Epigénesis Genética / Epigenoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión a Telómeros / Momento de Replicación del ADN / Epigénesis Genética / Epigenoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos