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Oxazepam and cognitive reappraisal: A randomised experiment.
Nilsonne, Gustav; Tamm, Sandra; Golkar, Armita; Olsson, Andreas; Sörman, Karolina; Howner, Katarina; Kristiansson, Marianne; Ingvar, Martin; Petrovic, Predrag.
Afiliación
  • Nilsonne G; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Tamm S; Department of Psychology, Stockholm University, Stockholm, Sweden.
  • Golkar A; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Olsson A; Department of Psychology, Stockholm University, Stockholm, Sweden.
  • Sörman K; Department of Psychology, University of Oxford, Oxford, England.
  • Howner K; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Kristiansson M; Department of Clinical Psychology, University of Amsterdam, Amsterdam, Netherlands.
  • Ingvar M; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Petrovic P; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
PLoS One ; 16(4): e0249065, 2021.
Article en En | MEDLINE | ID: mdl-33886568
BACKGROUND: Cognitive reappraisal is a strategy for emotional regulation, important in the context of anxiety disorders. It is not known whether anxiolytic effects of benzodiazepines affect cognitive reappraisal. AIMS: We aimed to investigate the effect of 25 mg oxazepam on cognitive reappraisal. METHODS: In a preliminary investigation, 33 healthy male volunteers were randomised to oxazepam or placebo, and then underwent an experiment where they were asked to use cognitive reappraisal to upregulate or downregulate their emotional response to images with negative or neutral emotional valence. We recorded unpleasantness ratings, skin conductance, superciliary corrugator muscle activity, and heart rate. Participants completed rating scales measuring empathy (Interpersonal Reactivity Index, IRI), anxiety (State-Trait Anxiety Inventory, STAI), alexithymia (Toronto Alexithymia Scale-20, TAS-20), and psychopathy (Psychopathy Personality Inventory-Revised, PPI-R). RESULTS: Upregulation to negative-valence images in the cognitive reappraisal task caused increased unpleasantness ratings, corrugator activity, and heart rate compared to downregulation. Upregulation to both negative- and neutral-valence images caused increased skin conductance responses. Oxazepam caused lower unpleasantness ratings to negative-valence stimuli, but did not interact with reappraisal instruction on any outcome. Self-rated trait empathy was associated with stronger responses to negative-valence stimuli, whereas self-rated psychopathic traits were associated with weaker responses to negative-valence stimuli. CONCLUSIONS: While 25 mg oxazepam caused lower unpleasantness ratings in response to negative-valence images, we did not observe an effect of 25 mg oxazepam on cognitive reappraisal.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxazepam / Ansiolíticos / Cognición / Regulación Emocional Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxazepam / Ansiolíticos / Cognición / Regulación Emocional Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos