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Neuro-COVID frequency and short-term outcome in the Northern Portuguese population.
Oliveira, Vanessa; Seabra, Mafalda; Rodrigues, Rita; Carvalho, Vanessa; Mendes, Michel; Pereira, Diogo; Caldeiras, Catarina; Martins, Bárbara; Silva, Renata; Azevedo, Ana; Lima, Maria João; Monteiro, Catarina; Varela, Ricardo; Malheiro, Sofia; Abreu, Miguel; Azevedo, Elsa; Leal Loureiro, José; Tedim Cruz, Vítor; Silva, Mário Rui; Magalhães, Rui; Silva, Carolina; Maia, Luís F; Correia, Manuel.
Afiliación
  • Oliveira V; Neurology Department, Centro Hospitalar Universitário do Porto-Hospital de Santo António, Porto, Portugal.
  • Seabra M; Neurology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal.
  • Rodrigues R; Neurology Department, Centro Hospitalar Entre-Douro e Vouga, Santa Maria da Feira, Portugal.
  • Carvalho V; Neurology Department, Unidade Local de Saúde de Matosinhos, Matosinhos, Portugal.
  • Mendes M; Neurology Department, Centro Hospitalar Trás-os-Montes e Alto-douro, Vila Real, Portugal.
  • Pereira D; Neurology Department, Centro Hospitalar Universitário do Porto-Hospital de Santo António, Porto, Portugal.
  • Caldeiras C; Neurology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal.
  • Martins B; Neurology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal.
  • Silva R; Neurology Department, Centro Hospitalar Entre-Douro e Vouga, Santa Maria da Feira, Portugal.
  • Azevedo A; Neurology Department, Centro Hospitalar Entre-Douro e Vouga, Santa Maria da Feira, Portugal.
  • Lima MJ; Neurology Department, Unidade Local de Saúde de Matosinhos, Matosinhos, Portugal.
  • Monteiro C; Neurology Department, Centro Hospitalar Universitário do Porto-Hospital de Santo António, Porto, Portugal.
  • Varela R; Neurology Department, Centro Hospitalar Universitário do Porto-Hospital de Santo António, Porto, Portugal.
  • Malheiro S; Neurology Department, Centro Hospitalar Universitário do Porto-Hospital de Santo António, Porto, Portugal.
  • Abreu M; Infectious Diseases Department, Centro Hospitalar Universitário do Porto-Hospital de Santo António, Porto, Portugal.
  • Azevedo E; Neurology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal.
  • Leal Loureiro J; Neurology Department, Centro Hospitalar Entre-Douro e Vouga, Santa Maria da Feira, Portugal.
  • Tedim Cruz V; Neurology Department, Unidade Local de Saúde de Matosinhos, Matosinhos, Portugal.
  • Silva MR; Epidemiological Research Unit, Institute of Public Health, University of Porto, Porto, Portugal.
  • Magalhães R; Neurology Department, Centro Hospitalar Trás-os-Montes e Alto-douro, Vila Real, Portugal.
  • Silva C; Abel Salazar Institute of Biomedical Sciences, University of Porto, Porto, Portugal.
  • Maia LF; Abel Salazar Institute of Biomedical Sciences, University of Porto, Porto, Portugal.
  • Correia M; Neurology Department, Centro Hospitalar Universitário do Porto-Hospital de Santo António, Porto, Portugal.
Eur J Neurol ; 28(10): 3360-3368, 2021 10.
Article en En | MEDLINE | ID: mdl-33884707
BACKGROUND AND PURPOSE: COVID-19-related acute neurological phenotypes are being increasingly recognised, with neurological complications reported in more than 30% of hospitalised patients. However, multicentric studies providing a population-based perspective are lacking. METHODS: We conducted a retrospective multicentric study at five hospitals in Northern Portugal, representing 45.1% of all hospitalised patients in this region, between 1 March and 30 June 2020. RESULTS: Among 1261 hospitalised COVID-19 patients, 457 (36.2%) presented neurological manifestations, corresponding to a rate of 357 per 1000 in the North Region. Patients with neurologic manifestations were younger (68.0 vs. 71.2 years, p = 0.002), and the most frequent neurological symptoms were headache (13.4%), delirium (10.1%), and impairment of consciousness (9.7%). Acute well-defined central nervous system (CNS) involvement was found in 19.1% of patients, corresponding to a rate of 217 per 1000 hospitalised patients in the whole region. Assuming that all patients with severe neurological events were hospitalised, we extrapolated our results to all COVID-19 patients in the region, estimating that 116 will have a severe neurological event, corresponding to a rate of nine per 1000 (95% CI = 7-11). Overall case fatality in patients presenting neurological manifestations was 19.8%, increasing to 32.6% among those with acute well-defined CNS involvement. CONCLUSIONS: We characterised the population of hospitalised COVID-19 patients in Northern Portugal and found that neurological symptoms are common and associated with a high degree of disability at discharge. CNS involvement with criteria for in-hospital admission was observed in a significant proportion of patients. This knowledge provides the tools for adequate health planning and for improving COVID-19 multidisciplinary patient care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Enfermedades del Sistema Nervioso Tipo de estudio: Observational_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Enfermedades del Sistema Nervioso Tipo de estudio: Observational_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido