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Nocturnal dipping of heart rate is impaired in children with Down syndrome and sleep disordered breathing.
Bassam, Ahmad; Thacker, Julie; Walter, Lisa M; Davey, Margot J; Nixon, Gillian M; Horne, Rosemary Sc.
Afiliación
  • Bassam A; Department of Paediatrics, Monash University, The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.
  • Thacker J; Department of Paediatrics, Monash University, The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.
  • Walter LM; Department of Paediatrics, Monash University, The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.
  • Davey MJ; Department of Paediatrics, Monash University, The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, Victoria, Australia.
  • Nixon GM; Department of Paediatrics, Monash University, The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, Victoria, Australia.
  • Horne RS; Department of Paediatrics, Monash University, The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia. Electronic address: rosemary.horne@monash.edu.
Sleep Med ; 81: 466-473, 2021 05.
Article en En | MEDLINE | ID: mdl-33872947
BACKGROUND: Children with Down syndrome (DS) are at increased risk for sleep disordered breathing (SDB), which can have adverse effects on the cardiovascular system. In adults with SDB, nocturnal dipping of heart rate (HR) and blood pressure (BP) is reduced, and this is associated with an increased risk of future cardiovascular events. We aimed to compare nocturnal dipping of HR and pulse transit time (PTT) (a surrogate inverse measure of BP change) in children with DS and SDB to those of typically developing (TD) children with and without SDB. METHODS: 19 children with DS (3-18 years) were age and sex matched with 19 TD children without SDB (TD-) and with 19 TD children with matched severity of SDB (TD+). Nocturnal dipping was assessed as the percentage change in HR and PTT from wake before sleep onset to total sleep, N2, N3 and REM sleep across the night and to the first cycle of sleep. RESULTS: Children with DS exhibited reduced nocturnal dipping of HR during total sleep, N2, N3 and REM sleep and increased PTT (reduced BP dipping) in N2 sleep. Fewer children with DS exhibited a greater than 10% fall in HR between wake and N2 or REM sleep compared to TD+ children. CONCLUSIONS: Our findings demonstrate significantly reduced nocturnal dipping of HR in children with DS compared to TD children matched for SDB severity, suggesting SDB has a greater cardiovascular effect in these children. Further studies are required to fully understand the mechanisms involved and to assess if treatment of SDB improves nocturnal dipping.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes de la Apnea del Sueño / Síndrome de Down Límite: Adult / Child / Humans Idioma: En Revista: Sleep Med Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes de la Apnea del Sueño / Síndrome de Down Límite: Adult / Child / Humans Idioma: En Revista: Sleep Med Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos