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Role of endothelial biomarkers in predicting acute kidney injury in Bothrops envenoming.
Mota, Sandra Mara Brasileiro; Albuquerque, Polianna Lemos Moura Moreira; Meneses, Gdayllon Cavalcante; da Silva Junior, Geraldo Bezerra; Martins, Alice Maria Costa; De Francesco Daher, Elizabeth.
Afiliación
  • Mota SMB; Medical Sciences Graduate Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: sandramarabrasileiro@gmail.com.
  • Albuquerque PLMM; University of Fortaleza, Fortaleza, Ceará, Brazil.
  • Meneses GC; Medical Sciences Graduate Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • da Silva Junior GB; University of Fortaleza, Fortaleza, Ceará, Brazil.
  • Martins AMC; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • De Francesco Daher E; Medical Sciences Graduate Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Toxicol Lett ; 345: 61-66, 2021 Jul 01.
Article en En | MEDLINE | ID: mdl-33872748
Acute kidney injury (AKI) is a frequent and potentially fatal complication of snakebites. In the setting of snakebites, endothelial biomarkers may be used to predict disease severity and can play a major role in AKI pathophysiology. The aim of this study was to investigate the potential role of endothelial biomarkers in predicting AKI in Bothrops envenoming. Therefore, blood and urine samples were collected from 26 patients admitted to the emergency department after Bothrops envenoming at 3 different post-bite points in time: on admission (up to 8 h post-bite), 12-16 h, and 24-28 h post-bite, to investigate the time course of endothelial biomarkers in AKI following Bothrops snakebites. The diagnostic performance of injury biomarkers in Bothrops envenomation was evaluated. AKI was diagnosed using the Kidney Disease Improving Global Outcomes (KDIGO) criteria. There was an association between endothelial injury and increased risk for AKI in bothropic envenoming. Angiopoietin- 1 (Ang-1) and Vascular cell adhesion protein-1 (VCAM-1) were useful biomarkers to predict mild AKI [AUC-ROC: Ang-1 0.82, VCAM-1 0.76] within the interval of 8-16 h post Bothrops snakebites. The use of endothelial biomarkers VCAM-1 e Ang-1 within 12-16 h post-bite may be useful in the early stage of mild AKI related to Bothrops envenoming and might have an effect on the early intervention for renal protection in less severe Bothrops-related AKI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mordeduras de Serpientes / Bothrops / Molécula 1 de Adhesión Celular Vascular / Venenos de Crotálidos / Células Endoteliales / Angiopoyetina 1 / Lesión Renal Aguda / Riñón Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Toxicol Lett Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mordeduras de Serpientes / Bothrops / Molécula 1 de Adhesión Celular Vascular / Venenos de Crotálidos / Células Endoteliales / Angiopoyetina 1 / Lesión Renal Aguda / Riñón Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Toxicol Lett Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos