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Choroidal vascular changes in acne patients under isotretinoin treatment.
Sekeryapan Gediz, Berrak; Corak Eroglu, Fatma; Aydogan, Mert; Aydugan, Merve Temmuz; Kilinc Hekimsoy, Hilal.
Afiliación
  • Sekeryapan Gediz B; Ophthalmology Department, Ulucanlar Eye Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Corak Eroglu F; Ophthalmology Department, Ulucanlar Eye Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Aydogan M; Dermatology Department, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Aydugan MT; Ophthalmology Department, Ulucanlar Eye Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
  • Kilinc Hekimsoy H; Ophthalmology Department, Ulucanlar Eye Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Cutan Ocul Toxicol ; 40(2): 125-129, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33866916
PURPOSE: The aim of this study was to evaluate the potential changes in choroidal vasculature in nodulocystic acne patients under isotretinoin treatment by using choroidal thickness (CT), choroidal vascularity index (CVI), and choriocapillaris (CC) flow area. MATERIALS AND METHODS: This prospective study included nodulocystic acne patients under isotretinoin treatment and healthy controls. All patients underwent enhanced depth imaging-optical coherence tomography (EDI-OCT) imaging to assess the subfoveal CT and submacular CVI, and optical coherence tomography angiography (OCTA) imaging to evaluate the CC flow area. RESULTS: A total of 25 patients with acne and 23 controls were included. The mean duration of the treatment was 7.20 ± 0.79 months and the mean daily isotretinoin dose was 38.7 ± 2.8 mg in the acne group. The mean CT and CVI values were significantly higher in the acne group compared to the control group (p = 0.005 and p = 0.027, respectively). The cumulative isotretinoin dose was positively correlated with subfoveal CT and submacular CVI (r = 0.434, p = 0.015 and r = 0.385, p = 0.033, respectively). Regarding the CC flow area, the values for area with a radius of 1 mm, 2 mm and 3 mm were lower in the acne group than in the control group; however, the difference was not significant (p > 0.05, all values). CONCLUSION: After a mean 7-month course of isotretinoin treatment, subfoveal CT and submacular CVI values were significantly higher in the nodulocyctic acne patients. Whether the choroidal changes are permanent or not should be investigated in future studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isotretinoína / Coroides / Acné Vulgar / Fármacos Dermatológicos Tipo de estudio: Clinical_trials / Observational_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Cutan Ocul Toxicol Asunto de la revista: DERMATOLOGIA / OFTALMOLOGIA / TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isotretinoína / Coroides / Acné Vulgar / Fármacos Dermatológicos Tipo de estudio: Clinical_trials / Observational_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Cutan Ocul Toxicol Asunto de la revista: DERMATOLOGIA / OFTALMOLOGIA / TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido