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Role of 5-HT1A receptors in the ventral hippocampus in the regulation of anxiety- and panic-related defensive behaviors in rats.
Hernandes, Paloma Molina; Batistela, Matheus Fitipaldi; Vilela-Costa, Heloísa Helena; Sant'Ana, Ana Beatriz; Kumpel, Vinicíus Dias; Tirapelle, Mariane Cariati; Bom, Ariela de Oliveira Pedro; de Andrade, Telma Gonçalves Carneiro Spera; Zangrossi, Hélio.
Afiliación
  • Hernandes PM; Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
  • Batistela MF; Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
  • Vilela-Costa HH; Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
  • Sant'Ana AB; Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
  • Kumpel VD; Department of Biological Science, São Paulo State University (UNESP), Assis, SP, Brazil.
  • Tirapelle MC; Department of Biological Science, São Paulo State University (UNESP), Assis, SP, Brazil.
  • Bom AOP; Department of Biological Science, São Paulo State University (UNESP), Assis, SP, Brazil.
  • de Andrade TGCS; Department of Biological Science, São Paulo State University (UNESP), Assis, SP, Brazil.
  • Zangrossi H; Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil. Electronic address: zangross@fmrp.usp.br.
Behav Brain Res ; 408: 113296, 2021 06 25.
Article en En | MEDLINE | ID: mdl-33862061
Changes in 5-HT1A receptor (5-HT1AR)-mediated neurotransmission in the hippocampus have been associated with anxiety, depression and in the mode of action of antidepressant drugs. It has been commonly accepted that whereas the dorsal pole of the hippocampus (DH) is involved in cognitive processing, the ventral pole (VH) is associated with emotional regulation. However, to date, only a few studies have directly addressed the role played by VH 5-HT1ARs in anxiety and panic processing, and their results are conflicting. Here we report that intra-VH administration of the 5-HT1A receptor agonist 8-OH-DPAT, the endogenous agonist serotonin (5-HT), or the standard anxiolytic benzodiazepine midazolam impaired the acquisition of inhibitory avoidance in the elevated T-maze (ETM) of male Wistar rats, indicating an anxiolytic effect. Conversely, local injection of the 5-HT1AR antagonist WAY-100635 caused the opposite effect. These results were equally found in the Vogel conflict test. None of these drugs interfered with locomotor activity in the open-field test, nor did they alter the expression of the escape response in the ETM, a defensive behavior associated with panic. Pre-injection of a sub-effective dose of WAY-100635 in the VH blocked the anxiolytic effect of 5-HT or 8-OH-DPAT in the Vogel test, confirming the involvement of 5-HT1AR for this behavioral effect. The effect in this test was anxiety-selective as none of the drugs affected water consumption or nociception. In conclusion, our results suggest that 5-HT1ARs in the VH play a tonic inhibitory role in anxiety processing. These receptors, however, are not involved in the regulation of panic-related escape behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Pánico / Conducta Animal / Receptor de Serotonina 5-HT1A / Hipocampo Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Pánico / Conducta Animal / Receptor de Serotonina 5-HT1A / Hipocampo Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos