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The Relationship between Hepatic Myeloid-Derived Suppressor Cells and Clinicopathological Parameters in Patients with Chronic Liver Disease.
Zhou, Zhijia; Lai, Penghua; Zhang, Shaoliang; Wang, Yujie; Qu, Ning; Lu, Dawei; Gao, Liangqin; Xu, Lingxia; Yang, Yanmiao; Zhang, Ting; Sun, Xue; Zheng, Xiaoting; Liu, Yaoyu; Liang, Huiqing; Chen, Shaodong.
Afiliación
  • Zhou Z; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Lai P; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Zhang S; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Wang Y; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Qu N; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Lu D; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Gao L; Hospital of Xiamen University, Xiamen, Fujian, China.
  • Xu L; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Yang Y; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Zhang T; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Sun X; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • Zheng X; Fujian University of Traditional Chinese Medicine, Fujian, China.
  • Liu Y; Fujian University of Traditional Chinese Medicine, Fujian, China.
  • Liang H; Liver Disease Center, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, China.
  • Chen S; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Biomed Res Int ; 2021: 6612477, 2021.
Article en En | MEDLINE | ID: mdl-33860040
Myeloid-derived suppressor cells (MDSCs) have attracted attention due to their important role in inflammation. Several studies have investigated the involvement of MDSCs in chronic liver disease. However, due to the difference of MDSC phenotypes, patient types, and sample sources among the studies, the results are inconsistent and controversial. We took advantage of a large well-defined cohort of 98 (24 patients with CHB, 18 with NAFLD, 13 with HCC, 16 with PBC, and 27 with AIH) patients with liver inflammation and 12 healthy controls to investigate the expression of MDSCs, and the relationships between the expression of hepatic MDSCs and the clinical characteristics were analyzed. We found that the expression of CD11b+CD33+ MDSCs is closely related to chronic liver disease and positively correlated with clinical parameters such as ALT, AST, and globulin. Ultimately, the present study suggests that hepatic CD11b+CD33+ MDSCs are increased in HCC and AIH and positively correlate with the liver stages of hepatitis activity and liver fibrosis stage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Supresoras de Origen Mieloide / Hepatopatías Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Res Int Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Supresoras de Origen Mieloide / Hepatopatías Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Res Int Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos