Your browser doesn't support javascript.
loading
Ultrasonic actuation of a fine-needle improves biopsy yield.
Perra, Emanuele; Lampsijärvi, Eetu; Barreto, Gonçalo; Arif, Muhammad; Puranen, Tuomas; Hæggström, Edward; Pritzker, Kenneth P H; Nieminen, Heikki J.
Afiliación
  • Perra E; Medical Ultrasonics Laboratory (MEDUSA), Department of Neuroscience and Biomedical Engineering, Aalto University, 02150, Espoo, Finland.
  • Lampsijärvi E; Electronics Research Laboratory, Department of Physics, University of Helsinki, 00560, Helsinki, Finland.
  • Barreto G; Translational Immunology Research Program, University of Helsinki, 00100, Helsinki, Finland.
  • Arif M; Orton, 00280, Helsinki, Finland.
  • Puranen T; Medical Ultrasonics Laboratory (MEDUSA), Department of Neuroscience and Biomedical Engineering, Aalto University, 02150, Espoo, Finland.
  • Hæggström E; Electronics Research Laboratory, Department of Physics, University of Helsinki, 00560, Helsinki, Finland.
  • Pritzker KPH; Electronics Research Laboratory, Department of Physics, University of Helsinki, 00560, Helsinki, Finland.
  • Nieminen HJ; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5S 1A8, Canada.
Sci Rep ; 11(1): 8234, 2021 04 15.
Article en En | MEDLINE | ID: mdl-33859220
Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend to several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with an increase in tissue yield by 3-6× in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ultrasonografía Intervencional / Agujas Tipo de estudio: Evaluation_studies Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ultrasonografía Intervencional / Agujas Tipo de estudio: Evaluation_studies Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido