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Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.
Israeli, Hadar; Degtjarik, Oksana; Fierro, Fabrizio; Chunilal, Vidicha; Gill, Amandeep Kaur; Roth, Nicolas J; Botta, Joaquin; Prabahar, Vadivel; Peleg, Yoav; Chan, Li F; Ben-Zvi, Danny; McCormick, Peter J; Niv, Masha Y; Shalev-Benami, Moran.
Afiliación
  • Israeli H; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Degtjarik O; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Fierro F; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Chunilal V; The Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot, Israel.
  • Gill AK; The Fritz Haber Center for Molecular Dynamics, The Hebrew University, Jerusalem, Israel.
  • Roth NJ; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK.
  • Botta J; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK.
  • Prabahar V; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK.
  • Peleg Y; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK.
  • Chan LF; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
  • Ben-Zvi D; Structural Proteomics Unit (SPU), Life Sciences Core Facilities (LSCF), Weizmann Institute of Science, Rehovot 7610001, Israel.
  • McCormick PJ; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK.
  • Niv MY; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. moransb@weizmann.ac.il p.mccormick@qmul.ac.uk masha.niv@mail.huji.ac.il danny.ben-zvi@mail.huji.ac.il.
  • Shalev-Benami M; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, Charterhouse Square, London, UK. moransb@weizmann.ac.il p.mccormick@qmul.ac.uk masha.niv@mail.huji.ac.il danny.ben-zvi@mail.huji.ac.il.
Science ; 372(6544): 808-814, 2021 05 21.
Article en En | MEDLINE | ID: mdl-33858992
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saciedad / Alfa-MSH / Fármacos Antiobesidad / Receptor de Melanocortina Tipo 4 Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saciedad / Alfa-MSH / Fármacos Antiobesidad / Receptor de Melanocortina Tipo 4 Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos