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Speech Biomarkers in Rapid Eye Movement Sleep Behavior Disorder and Parkinson Disease.
Rusz, Jan; Hlavnicka, Jan; Novotný, Michal; Tykalová, Tereza; Pelletier, Amelie; Montplaisir, Jacques; Gagnon, Jean-Francois; Dusek, Petr; Galbiati, Andrea; Marelli, Sara; Timm, Paul C; Teigen, Luke N; Janzen, Annette; Habibi, Mahboubeh; Stefani, Ambra; Holzknecht, Evi; Seppi, Klaus; Evangelista, Elisa; Rassu, Anna Laura; Dauvilliers, Yves; Högl, Birgit; Oertel, Wolfgang; St Louis, Erik K; Ferini-Strambi, Luigi; Ruzicka, Evzen; Postuma, Ronald B; Sonka, Karel.
Afiliación
  • Rusz J; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
  • Hlavnicka J; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Novotný M; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
  • Tykalová T; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
  • Pelletier A; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
  • Montplaisir J; Department of Neurology, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.
  • Gagnon JF; Center for Advanced Research in Sleep Medicine, CIUSSS-NIM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
  • Dusek P; Center for Advanced Research in Sleep Medicine, CIUSSS-NIM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
  • Galbiati A; Center for Advanced Research in Sleep Medicine, CIUSSS-NIM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.
  • Marelli S; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Timm PC; Sleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy.
  • Teigen LN; Sleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy.
  • Janzen A; Mayo Center for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN.
  • Habibi M; Department of Neurology, Mayo Clinic College of Medicine and Science, Rochester, MN.
  • Stefani A; Mayo Center for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN.
  • Holzknecht E; Department of Neurology, Mayo Clinic College of Medicine and Science, Rochester, MN.
  • Seppi K; Department of Neurology, Philipps University Marburg, Marburg, Germany.
  • Evangelista E; Department of Neurology, Philipps University Marburg, Marburg, Germany.
  • Rassu AL; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Dauvilliers Y; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Högl B; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Oertel W; National Reference Network for Narcolepsy, Sleep-Wake Disorder Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, INSERM, University of Montpellier, Montpellier, France.
  • St Louis EK; National Reference Network for Narcolepsy, Sleep-Wake Disorder Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, INSERM, University of Montpellier, Montpellier, France.
  • Ferini-Strambi L; National Reference Network for Narcolepsy, Sleep-Wake Disorder Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, INSERM, University of Montpellier, Montpellier, France.
  • Ruzicka E; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Postuma RB; Department of Neurology, Philipps University Marburg, Marburg, Germany.
  • Sonka K; Mayo Center for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN.
Ann Neurol ; 90(1): 62-75, 2021 07.
Article en En | MEDLINE | ID: mdl-33856074
OBJECTIVE: This multilanguage study used simple speech recording and high-end pattern analysis to provide sensitive and reliable noninvasive biomarkers of prodromal versus manifest α-synucleinopathy in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) and early-stage Parkinson disease (PD). METHODS: We performed a multicenter study across the Czech, English, German, French, and Italian languages at 7 centers in Europe and North America. A total of 448 participants (337 males), including 150 with iRBD (mean duration of iRBD across language groups 0.5-3.4 years), 149 with PD (mean duration of disease across language groups 1.7-2.5 years), and 149 healthy controls were recorded; 350 of the participants completed the 12-month follow-up. We developed a fully automated acoustic quantitative assessment approach for the 7 distinctive patterns of hypokinetic dysarthria. RESULTS: No differences in language that impacted clinical parkinsonian phenotypes were found. Compared with the controls, we found significant abnormalities of an overall acoustic speech severity measure via composite dysarthria index for both iRBD (p = 0.002) and PD (p < 0.001). However, only PD (p < 0.001) was perceptually distinct in a blinded subjective analysis. We found significant group differences between PD and controls for monopitch (p < 0.001), prolonged pauses (p < 0.001), and imprecise consonants (p = 0.03); only monopitch was able to differentiate iRBD patients from controls (p = 0.004). At the 12-month follow-up, a slight progression of overall acoustic speech impairment was noted for the iRBD (p = 0.04) and PD (p = 0.03) groups. INTERPRETATION: Automated speech analysis might provide a useful additional biomarker of parkinsonism for the assessment of disease progression and therapeutic interventions. ANN NEUROL 2021;90:62-75.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Habla / Trastorno de la Conducta del Sueño REM Tipo de estudio: Clinical_trials Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Ann Neurol Año: 2021 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Habla / Trastorno de la Conducta del Sueño REM Tipo de estudio: Clinical_trials Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Ann Neurol Año: 2021 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos