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Serum and urine ANGPTL8 expression levels are associated with hyperlipidemia and proteinuria in primary nephrotic syndrome.
Li, Yue; Liu, Qingju; Kang, Chengdong; Cui, Weijing; Xu, Zichuan; Zhong, Fu; Gao, Xia.
Afiliación
  • Li Y; Graduate School, Gansu University of Chinese Medicine, Lanzhou city, 730000, China.
  • Liu Q; Graduate School, Gansu University of Chinese Medicine, Lanzhou city, 730000, China.
  • Kang C; Departmentof Pediatrics, the Fifth People's Hospital of Chengdu, Chengdu city, 611130, China.
  • Cui W; Department of Nephrology, Guangzhou Women and Children's Medical Center, Guangzhou city, 510623, China.
  • Xu Z; Pediatric Department, Gansu Provincial Hospital, Lanzhou city, 730000, China.
  • Zhong F; Department of Nephrology, Guangzhou Women and Children's Medical Center, Guangzhou city, 510623, China.
  • Gao X; Department of Nephrology, Guangzhou Women and Children's Medical Center, Guangzhou city, 510623, China.
BMC Nephrol ; 22(1): 130, 2021 04 14.
Article en En | MEDLINE | ID: mdl-33853533
BACKGROUND: This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria. METHODS: ANGPTL8 levels were determined using an enzyme-linked immunosorbent assay in 133 subjects with PNS and 60 healthy controls. RESULTS: Compared with healthy controls, subjects with primary nephrotic syndrome had higher levels of serum and urine ANGPTL8 (P < 0.001). In primary nephrotic syndrome patients, serum ANGPTL8 was positively correlated with cholesterol (r = 0.209, P < 0.05) and triglycerides (r = 0.412, P < 0.001), while there was no correlation with 24 hUTP. Urine ANGPTL8 was positively correlated with high-density lipoprotein cholesterol (r = 0.181, P < 0.05) and was significantly negatively correlated with creatinine (r = - 0.323, P < 0.001), eGFR (r = - 0, P < 0.001) and 24 hUTP (r = - 0.268, P = 0.002). Interestingly, the urine ANGPTL8 concentrations in membranous nephropathy and mesangial proliferative glomerulonephritis pathological types were different. CONCLUSIONS: Serum and urine ANGPTL8 levels in primary nephrotic syndrome patients were correlated with blood lipid levels and proteinuria, respectively, suggesting that ANGPTL8 may play a role in the development of primary nephrotic syndrome hyperlipidemia and proteinuria.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteinuria / Hormonas Peptídicas / Proteína 8 Similar a la Angiopoyetina / Hiperlipidemias / Síndrome Nefrótico Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteinuria / Hormonas Peptídicas / Proteína 8 Similar a la Angiopoyetina / Hiperlipidemias / Síndrome Nefrótico Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido