Lessons from Cancer Metabolism for Pulmonary Arterial Hypertension and Fibrosis.
Am J Respir Cell Mol Biol
; 65(2): 134-145, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-33844936
Metabolism is essential for a living organism to sustain life. It provides energy to a cell by breaking down compounds (catabolism) and supplies building blocks for the synthesis of macromolecules (anabolism). Signal transduction pathways tightly regulate mammalian cellular metabolism. Simultaneously, metabolism itself serves as a signaling pathway to control many cellular processes, such as proliferation, differentiation, cell death, gene expression, and adaptation to stress. Considerable progress in the metabolism field has come from understanding how cancer cells co-opt metabolic pathways for growth and survival. Recent data also show that several metabolic pathways may participate in the pathogenesis of lung diseases, some of which could be promising therapeutic targets. In this translational review, we will outline the basic metabolic principles learned from the cancer metabolism field as they apply to the pathogenesis of pulmonary arterial hypertension and fibrosis and will place an emphasis on therapeutic potential.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ciclo del Ácido Cítrico
/
Tomografía de Emisión de Positrones
/
Redes y Vías Metabólicas
/
Hipertensión Arterial Pulmonar
/
Glucólisis
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Am J Respir Cell Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2021
Tipo del documento:
Article
Pais de publicación:
Estados Unidos