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Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes.
Men, Hongsheng; Hankins, Miriam A; Bock, Anagha S; Beaton, Benjamin P; Davis, Daniel J; Chesney, Kari L; Bryda, Elizabeth C.
Afiliación
  • Men H; Rat Resource and Research Center, University of Missouri, Columbia, MO, 65201, USA.
  • Hankins MA; Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, 65201, USA.
  • Bock AS; Rat Resource and Research Center, University of Missouri, Columbia, MO, 65201, USA.
  • Beaton BP; Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, 65201, USA.
  • Davis DJ; Rat Resource and Research Center, University of Missouri, Columbia, MO, 65201, USA.
  • Chesney KL; Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, 65201, USA.
  • Bryda EC; Division of Animal Sciences, University of Missouri, Columbia, MO, 65201, USA.
Mamm Genome ; 32(3): 173-182, 2021 06.
Article en En | MEDLINE | ID: mdl-33843019
Mutations and single base pair polymorphisms in various genes have been associated with increased susceptibility to inflammatory bowel disease (IBD). We have created a series of rat strains carrying targeted genetic alterations within three IBD susceptibility genes: Nod2, Atg16l1, and Il23r, using CRISPR/Cas9 genome editing technology. Knock-out alleles and alleles with known human susceptibility polymorphisms were generated on three different genetic backgrounds: Fischer, Lewis and Sprague Dawley. The availability of these rat models will contribute to our understanding of the basic biological roles of these three genes as well as provide new potential IBD animal models.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Receptores de Interleucina / Predisposición Genética a la Enfermedad / Proteína Adaptadora de Señalización NOD2 Límite: Animals / Humans Idioma: En Revista: Mamm Genome Asunto de la revista: GENETICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Receptores de Interleucina / Predisposición Genética a la Enfermedad / Proteína Adaptadora de Señalización NOD2 Límite: Animals / Humans Idioma: En Revista: Mamm Genome Asunto de la revista: GENETICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos