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Paving the way for small-molecule drug discovery.
Ma, Yu-Shui; Xin, Rui; Yang, Xiao-Li; Shi, Yi; Zhang, Dan-Dan; Wang, Hui-Min; Wang, Pei-Yao; Liu, Ji-Bin; Chu, Kai-Jian; Fu, Da.
Afiliación
  • Ma YS; National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology Changsha 410004, Hunan, China.
  • Xin R; Cancer Institute, Nantong Tumor Hospital Nantong 226631, China.
  • Yang XL; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Shi Y; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Zhang DD; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Wang HM; Cancer Institute, Nantong Tumor Hospital Nantong 226631, China.
  • Wang PY; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Liu JB; Cancer Institute, Nantong Tumor Hospital Nantong 226631, China.
  • Chu KJ; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
  • Fu D; Cancer Institute, Nantong Tumor Hospital Nantong 226631, China.
Am J Transl Res ; 13(3): 853-870, 2021.
Article en En | MEDLINE | ID: mdl-33841626
Small-molecule drugs are organic compounds affecting molecular pathways by targeting important proteins, which have a low molecular weight, making them penetrate cells easily. Small-molecule drugs can be developed from leads derived from rational drug design or isolated from natural resources. As commonly used medications, small-molecule drugs can be taken orally, which enter cells to act on intracellular targets. These characteristics make small-molecule drugs promising candidates for drug development, and they are increasingly favored in the pharmaceutical market. Despite the advancements in molecular genetics and effective new processes in drug development, the drugs currently used in clinical practice are inadequate due to their poor efficacy or severe side effects. Therefore, developing new safe and efficient drugs is a top priority for disease control and curing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Transl Res Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Transl Res Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos