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Melatonin administration attenuates acute stress by inducing sleep state in zebrafish (Danio rerio).
Lunkes, Luciana Crepaldi; Paiva, Isadora Marques; Egger, Renata Catão; Braga, Weslley Fernandes; Alvarez-Leite, Jacqueline Isaura; da Cunha Barreto-Vianna, André Rodrigues; Murgas, Luis David Solis.
Afiliación
  • Lunkes LC; Federal University of Lavras, Graduate Program in Veterinary Sciences, Department of Veterinary Medicine, Lavras, MG, Brazil.
  • Paiva IM; Federal University of Minas Gerais, Graduate Program in Genetics, Institute of Biological Sciences, Belo Horizonte, MG, Brazil.
  • Egger RC; Federal University of Lavras, Graduate Program in Veterinary Sciences, Department of Veterinary Medicine, Lavras, MG, Brazil.
  • Braga WF; Federal University of Minas Gerais, Postgraduate Program in Biochemistry and Immunology, Department of Biochemistry and Immunology, Belo Horizonte, MG, Brazil.
  • Alvarez-Leite JI; Federal University of Minas Gerais, Postgraduate Program in Biochemistry and Immunology, Department of Biochemistry and Immunology, Belo Horizonte, MG, Brazil.
  • da Cunha Barreto-Vianna AR; Federal University of Paraná, Department of Biocience, Palotina, PR, Brazil.
  • Murgas LDS; Federal University of Lavras, Graduate Program in Veterinary Sciences, Department of Veterinary Medicine, Lavras, MG, Brazil. Electronic address: lsmurgas@dmv.ufla.br.
Comp Biochem Physiol C Toxicol Pharmacol ; 246: 109044, 2021 Aug.
Article en En | MEDLINE | ID: mdl-33838315
Melatonin plays a fundamental homeostatic role in basic biological functions, and an anti-stress role has been also proposed for this hormone. This study aimed to evaluate hormonal, enzymatic and behavioral parameters of zebrafish that received administration of melatonin and were submitted to acute stress. A total of 120 wild-type zebrafish were divided into five groups: naïve control (N), negative control group (Stress/C), positive control treated with diazepam (Stress/Diaz), treatment with melatonin at dose 1 (Stress/Melt. 1) and treatment with melatonin at dose 2 (Stress/Melt. 2). The exposure to treatments (diazepam or melatonin) was performed prior to the acute stress protocol, based on a chase by a fishing net during 5 min followed by exposure to the air for 1 min. The body cortisol levels were assessed, as well as oxidative stress (thiobarbituric acid reactive substances, reactive species of oxygen and antioxidant activity), and fish behavior (open field test). Melatonin was able to modulate acute stress effects on zebrafish by inhibiting cortisol increasing levels, reducing locomotor parameters, inducing a sleep state, reducing lipid peroxidation and stimulating antioxidant enzymatic activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Estrés Oxidativo / Melatonina / Antioxidantes Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Comp Biochem Physiol C Toxicol Pharmacol Asunto de la revista: FARMACOLOGIA / TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Estrés Oxidativo / Melatonina / Antioxidantes Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Comp Biochem Physiol C Toxicol Pharmacol Asunto de la revista: FARMACOLOGIA / TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos