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Impact of Enteral Nutrition Within 24 Hours Versus Between 24 and 48 Hours in Patients With Severe Acute Pancreatitis: A Multicenter Retrospective Study.
Nakashima, Ikue; Horibe, Masayasu; Sanui, Masamitsu; Sasaki, Mitsuhito; Sawano, Hirotaka; Goto, Takashi; Ikeura, Tsukasa; Takeda, Tsuyoshi; Oda, Takuya; Yasuda, Hideto; Ogura, Yuki; Miyazaki, Dai; Kitamura, Katsuya; Chiba, Nobutaka; Ozaki, Tetsu; Yamashita, Takahiro; Koinuma, Toshitaka; Oshima, Taku; Yamamoto, Tomonori; Hirota, Morihisa; Moriya, Takashi; Shirai, Kunihiro; Izai, Junko; Takeda, Kazunori; Sekino, Motohiro; Iwasaki, Eisuke; Kanai, Takanori; Mayumi, Toshihiko.
Afiliación
  • Nakashima I; From the Department of Acute Care and General Medicine, Saiseikai Kumamoto Hospital, Kumamoto.
  • Sanui M; Department of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama.
  • Sasaki M; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo.
  • Sawano H; Senri Critical Care Medical Center, Osaka Saiseikai Senri Hospital, Osaka.
  • Goto T; Department of Anesthesiology and Intensive Care, Hiroshima City Hiroshima Citizens Hospital, Hiroshima.
  • Ikeura T; The Third Department of Internal Medicine, Kansai Medical University, Osaka.
  • Takeda T; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo.
  • Oda T; Department of General Internal Medicine, Iizuka Hospital, Fukuoka.
  • Yasuda H; Department of Emergency and Critical Care Medicine, Japanese Red Cross Musashino Hospital, Tokyo.
  • Ogura Y; Department of Gastroenterology and Hepatology, Tokyo Metropolitan Tama Medical Center, Tokyo.
  • Chiba N; Department of Emergency and Critical Care Medicine, Nihon University Hospital, Tokyo.
  • Ozaki T; From the Department of Acute Care and General Medicine, Saiseikai Kumamoto Hospital, Kumamoto.
  • Yamashita T; Emergency Medical Center, Fukuyama City Hospital, Hiroshima.
  • Koinuma T; Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University School of Medicine, Tochigi.
  • Oshima T; Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba.
  • Yamamoto T; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City University, Osaka.
  • Hirota M; Division of Gastroenterology, Tohoku University Hospital, Miyagi.
  • Moriya T; Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo.
  • Shirai K; Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu.
  • Izai J; Department of Surgery, Saka General Hospital.
  • Takeda K; Miyagi Branch Office, Health Insurance Claims Review and Reimbursement Services, Miyagi.
  • Sekino M; Division of Intensive Care, Nagasaki University Hospital, Nagasaki.
  • Iwasaki E; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine.
  • Kanai T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine.
  • Mayumi T; Department of Emergency Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.
Pancreas ; 50(3): 371-377, 2021 03 01.
Article en En | MEDLINE | ID: mdl-33835968
OBJECTIVES: In patients with severe acute pancreatitis (SAP), early enteral nutrition (EN) is recommended by major clinical practice guidelines, but the exact timing for the initiation of EN is unknown. METHODS: We conducted a post hoc analysis of the database for a multicenter (44 institutions) retrospective study of patients with SAP in Japan. The patients were classified into 3 groups according to the timing of EN initiation after the diagnosis of SAP: within 24 hours, between 24 and 48 hours, and more than 48 hours. The primary outcome was in-hospital mortality. RESULTS: Of the 1094 study patients, 176, 120, and 798 patients started EN within 24 hours, between 24 and 48 hours, and more than 48 hours after SAP diagnosis, respectively. On multivariable analysis, hospital mortality was significantly better with EN within 48 hours than with more than 48 hours (adjusted odds ratio, 0.49; 95% confidence interval, 0.29-0.83; P < 0.001) but did not significantly differ between the groups with EN starting within 24 hours and between 24 and 48 hours (P = 0.29). CONCLUSIONS: Enteral nutrition within 24 hours may not confer any additional benefit on clinical outcomes compared with EN between 24 and 48 hours.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatitis / Índice de Severidad de la Enfermedad / Nutrición Enteral / Hospitalización Tipo de estudio: Diagnostic_studies / Guideline / Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pancreas Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatitis / Índice de Severidad de la Enfermedad / Nutrición Enteral / Hospitalización Tipo de estudio: Diagnostic_studies / Guideline / Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pancreas Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos