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Imaging Biomarkers and Their Impact on Therapeutic Decision-Making in the Management of Neovascular Age-Related Macular Degeneration.
Wong, David T; Berger, Alan R; Bourgault, Serge; Chen, John; Colleaux, Kevin; Cruess, Alan F; Dookeran, Ravi I; Gauthier, Danny; Hurley, Bernard; Kapusta, Michael A; Kertes, Peter J; Qian, Cynthia X; Samad, Arif; Sheidow, Thomas; Whelan, James H.
Afiliación
  • Wong DT; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
  • Berger AR; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
  • Bourgault S; Department of Ophthalmology, Université Laval, Québec, Québec, Canada.
  • Chen J; Department of Ophthalmology, McGill University, Montréal, Québec, Canada.
  • Colleaux K; Department of Ophthalmology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
  • Cruess AF; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Dookeran RI; Department of Ophthalmology, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Gauthier D; Department of Ophthalmology, Université de Montréal, Montréal, Québec, Canada.
  • Hurley B; Department of Ophthalmology, University of Ottawa, Ottawa, Ontario, Canada.
  • Kapusta MA; Department of Ophthalmology, McGill University, Montréal, Québec, Canada.
  • Kertes PJ; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
  • Qian CX; Department of Ophthalmology, Université de Montréal, Montréal, Québec, Canada.
  • Samad A; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Sheidow T; Department of Ophthalmology, Western University, London, Ontario, Canada.
  • Whelan JH; Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada.
Ophthalmologica ; 244(4): 265-280, 2021.
Article en En | MEDLINE | ID: mdl-33823520
These recommendations, produced by a group of Canadian retina experts, have been developed to assist both retina specialists and general ophthalmologists in the management of vision-threatening neovascular age-related macular degeneration (nAMD). The recommendations are based on published evidence as well as collective experience and expertise in routine clinical practice. We provide an update on practice principles for optimal patient care, focusing on identified imaging biomarkers, in particular retinal fluid, as well as current and emerging therapeutic approaches. Algorithms for delivering high-quality care and improving long-term patient outcomes are provided, with an emphasis on timely and appropriate treatment to preserve and maintain vision. In the context of nAMD, increasing macular fluid or leakage on fluorescein angiography (FA) may indicate disease activity regardless of its location. Early elimination of intraretinal fluid (IRF) is of particular relevance as it is a prognostic indicator of worse visual outcomes. Robust referral pathways for second opinion and peer-to-peer consultations must be in place for cases not responding to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Degeneración Macular Húmeda / Degeneración Macular Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Ophthalmologica Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Degeneración Macular Húmeda / Degeneración Macular Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Ophthalmologica Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza