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A three-dimensional virtual mouse generates synthetic training data for behavioral analysis.
Bolaños, Luis A; Xiao, Dongsheng; Ford, Nancy L; LeDue, Jeff M; Gupta, Pankaj K; Doebeli, Carlos; Hu, Hao; Rhodin, Helge; Murphy, Timothy H.
Afiliación
  • Bolaños LA; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
  • Xiao D; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Ford NL; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
  • LeDue JM; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Gupta PK; Centre for High-Throughput Phenogenomics, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
  • Doebeli C; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
  • Hu H; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Rhodin H; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
  • Murphy TH; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
Nat Methods ; 18(4): 378-381, 2021 04.
Article en En | MEDLINE | ID: mdl-33820989
We developed a three-dimensional (3D) synthetic animated mouse based on computed tomography scans that is actuated using animation and semirandom, joint-constrained movements to generate synthetic behavioral data with ground-truth label locations. Image-domain translation produced realistic synthetic videos used to train two-dimensional (2D) and 3D pose estimation models with accuracy similar to typical manual training datasets. The outputs from the 3D model-based pose estimation yielded better definition of behavioral clusters than 2D videos and may facilitate automated ethological classification.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Imagenología Tridimensional Límite: Animals Idioma: En Revista: Nat Methods Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Imagenología Tridimensional Límite: Animals Idioma: En Revista: Nat Methods Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos