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Risk profile, antithrombotic treatment and clinical outcomes of patients in Nordic countries with atrial fibrillation - results from the GARFIELD-AF registry.
Pope, Marita Knudsen; Atar, Dan; Svilaas, Arne; Hole, Torstein; Nielsen, Jørn Dalsgaard; Hintze, Ulrik; Crisby, Milita; Raatikainen, Pekka; Airaksinen, K E Juhani; Virdone, Saverio; Pieper, Karen; Kayani, Gloria; Le Heuzey, Jean-Yves; Steffel, Jan; Stepinska, Janina; Bassand, Jean-Pierre; Camm, A John.
Afiliación
  • Pope MK; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Atar D; Hamar Hospital, Innlandet Hospital Trust, Hamar, Norway.
  • Svilaas A; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Hole T; Department of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway.
  • Nielsen JD; Nymoen Medical Centre, Kongsberg, Norway.
  • Hintze U; Lipid Clinic, Oslo University Hospital, Oslo, Norway.
  • Crisby M; Clinic of Medicine and Rehabilitation, More and Romsdal Hospital Trust, Alesund, Norway.
  • Raatikainen P; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
  • Airaksinen KEJ; Department of Cardiology, Copenhagen University Hospital, Copenhagen University, Copenhagen, Denmark.
  • Virdone S; Department of Cardiology, Hospital of South West Jutland, Esbjerg, University of Southern Denmark, Denmark.
  • Pieper K; Department of Neurobiology, Care Science and Society, Karolinska University Hospital, Stockholm, Sweden.
  • Kayani G; Department of Cardiology, Heart and Lung Center, Helsinki University Hospital, Tampere, Finland.
  • Le Heuzey JY; Heart Centre, Turku University Hospital and University of Turku, Turku, Finland.
  • Steffel J; Thrombosis Research Institute, London, UK.
  • Stepinska J; Thrombosis Research Institute, London, UK.
  • Bassand JP; Thrombosis Research Institute, London, UK.
  • Camm AJ; Georges Pompidou Hospital, René Descartes University, Paris, France.
Ann Med ; 53(1): 485-494, 2021 12.
Article en En | MEDLINE | ID: mdl-33818226
AIMS: The objective was to evaluate the clinical characteristics, management and two-year outcomes of patients with newly diagnosed non-valvular atrial fibrillation at risk for stroke in Nordic countries. METHODS: We examined the baseline characteristics, antithrombotic treatment, and two-year clinical outcomes of patients from four Nordic countries. RESULTS: A total of 52,080 patients were enrolled in the GARFIELD-AF. Out of 29,908 European patients, 2,396 were recruited from Nordic countries. The use of oral anticoagulants, alone or in combination with antiplatelet (AP), was higher in Nordic patients in all CHA2DS2-VASc categories: 0-1 (72.8% vs 60.3%), 2-3 (78.7% vs 72.9%) and ≥4 (79.2% vs 74.1%). In Nordic patients, NOAC ± AP was more frequently prescribed (32.0% vs 27.7%) and AP monotherapy was less often prescribed (10.4% vs 18.2%) when compared with Non-Nordic European patients. The rates (per 100 patient years) of all-cause mortality and non-haemorrhagic stroke/systemic embolism (SE) were similar in Nordic and Non-Nordic European patients [3.63 (3.11-4.23) vs 4.08 (3.91-4.26), p value = .147] and [0.98 (0.73-1.32) vs 1.02 (0.93-1.11), p value = .819], while major bleeding was significantly higher [1.66 (1.32-2.09) vs 1.01 (0.93-1.10), p value < .001]. CONCLUSION: Nordic patients had significantly higher major bleeding than Non-Nordic-European patients. In contrast, rates of all-cause mortality and non-haemorrhagic stroke/SE were comparable. CLINICAL TRIAL REGISTRATION: Unique identifier: NCT01090362. URL: http://www.clinicaltrials.gov. KEY MESSAGE: Nordic countries had significantly higher major bleeding than Non-Nordic-European countries. Rates of mortality and non-haemorrhagic stroke/SE were similar .
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Inhibidores de Agregación Plaquetaria / Accidente Cerebrovascular / Fibrinolíticos / Anticoagulantes Tipo de estudio: Clinical_trials / Etiology_studies / Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Inhibidores de Agregación Plaquetaria / Accidente Cerebrovascular / Fibrinolíticos / Anticoagulantes Tipo de estudio: Clinical_trials / Etiology_studies / Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido