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Pharmacokinetics of oral firocoxib in un-weaned calves.
Wagner, Sarah A; Fajt, Virginia R; Lo, Chih-Ping; Byrd, Christopher J.
Afiliación
  • Wagner SA; Department of Animal Sciences, North Dakota State University, Fargo, North Dakota, USA.
  • Fajt VR; Department of Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, USA.
  • Lo CP; Texas Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA.
  • Byrd CJ; Department of Animal Sciences, North Dakota State University, Fargo, North Dakota, USA.
J Vet Pharmacol Ther ; 44(5): 793-798, 2021 Sep.
Article en En | MEDLINE | ID: mdl-33817876
The objective of this study was to determine the pharmacokinetics of firocoxib after oral administration in un-weaned calves. Eight Holstein calves with a mean age of 36 days and a mean weight of 55 kg were administered a single oral dose of 227 mg firocoxib. The resulting mean dosage was 4.2 mg/kg (range 3.5-5.0 mg/kg). Blood was collected prior to drug administration and at 2, 4, 6, 8, 24, 48, 72, and 96 h after treatment. Firocoxib concentrations in plasma were determined using liquid chromatography-tandem mass spectrometry. Using computer software, pharmacokinetic parameters were found to fit best with a one-compartment model. Mean Cmax was 0.9 µg/ml (range 0.570-1.254), and Tmax was estimated to be 7 h (range 4-8 h). The estimated T1/2 was 15.3 h. The pharmacokinetics of firocoxib after oral dosing are similar to those in dogs, with the exception of a T1/2 that is approximately twice as long. Based on the similar pharmacokinetics, it is possible that a dose of 227 mg firocoxib orally could provide an analgesic effect in un-weaned calves.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonas / 4-Butirolactona Límite: Animals Idioma: En Revista: J Vet Pharmacol Ther Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonas / 4-Butirolactona Límite: Animals Idioma: En Revista: J Vet Pharmacol Ther Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido