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On the association between circulating biomarkers and atherosclerotic calcification in a cohort of arterial disease participants.
Cahalane, Rachel M; Barrett, Hilary E; Ross, Aisling M; Mulvihill, John J E; Purtill, Helen; Selvarajah, Logeswaran; O'Brien, Julie; Kavanagh, Eamon G; Moloneye, Michael A; Egan, Siobhan M; Leahy, Fiona C; Griffin, Tomás P; Islam, M N; O'Shea, Paul M; Walsh, Michael T; O'Connor, Eibhlís M.
Afiliación
  • Cahalane RM; BioScience and BioEngineering Research, Biomaterials Cluster, Bernal Institute, School of Engineering, University of Limerick, Ireland. Electronic address: rachelcahalane93@gmail.com.
  • Barrett HE; BioScience and BioEngineering Research, Biomaterials Cluster, Bernal Institute, School of Engineering, University of Limerick, Ireland. Electronic address: hilarybarrett91@gmail.com.
  • Ross AM; BioScience and BioEngineering Research, Biomaterials Cluster, Bernal Institute, School of Engineering, University of Limerick, Ireland. Electronic address: aisling.ross@ul.ie.
  • Mulvihill JJE; BioScience and BioEngineering Research, Biomaterials Cluster, Bernal Institute, School of Engineering, University of Limerick, Ireland; Health Research Institute, University of Limerick, Ireland. Electronic address: john.mulvihill@ul.ie.
  • Purtill H; Health Research Institute, University of Limerick, Ireland; Department of Mathematics and Statistics, Aging Research Centre, University of Limerick, Ireland. Electronic address: helen.purtill@ul.ie.
  • Selvarajah L; Department of Radiology, University Hospital Limerick, Ireland. Electronic address: logesselva@gmail.com.
  • O'Brien J; Department of Radiology, University Hospital Limerick, Ireland. Electronic address: juliemobrien@gmail.com.
  • Kavanagh EG; Department of Vascular Surgery, University Hospital Limerick, Ireland. Electronic address: eamon.kavanagh@icloud.com.
  • Moloneye MA; Department of Vascular Surgery, University Hospital Limerick, Ireland. Electronic address: tmoloney90@hotmail.com.
  • Egan SM; Clinical Research Support Unit, University Hospital Limerick, Ireland. Electronic address: SiobhanMary.Egan@hse.ie.
  • Leahy FC; Clinical Research Support Unit, University Hospital Limerick, Ireland. Electronic address: fionac.leahy@hse.ie.
  • Griffin TP; Centre for Endocrinology, Diabetes and Metabolism, Saolta University Health Care Group (SUHCG), Galway University Hospitals, Galway, Ireland; Regenerative Medicine Institute (REMEDI) at CÚRAM SFI Research Centre, School of Medicine, National University of Ireland Galway, Galway, Ireland. Electronic
  • Islam MN; Regenerative Medicine Institute (REMEDI) at CÚRAM SFI Research Centre, School of Medicine, National University of Ireland Galway, Galway, Ireland; Department of Clinical Biochemistry, University Hospital Galway, Ireland. Electronic address: nahidbmb2003@gmail.com.
  • O'Shea PM; Department of Clinical Biochemistry, University Hospital Galway, Ireland. Electronic address: PaulaM.OShea@hse.ie.
  • Walsh MT; BioScience and BioEngineering Research, Biomaterials Cluster, Bernal Institute, School of Engineering, University of Limerick, Ireland; Health Research Institute, University of Limerick, Ireland. Electronic address: Michael.walsh@ul.ie.
  • O'Connor EM; Health Research Institute, University of Limerick, Ireland; Department of Biological Sciences, School of Natural Sciences, University of Limerick, Ireland; Alimentary Pharmabiotic Centre, Microbiome Institute, University College Cork, Ireland. Electronic address: eibhlis.oconnor@ul.ie.
Nutr Metab Cardiovasc Dis ; 31(5): 1533-1541, 2021 05 06.
Article en En | MEDLINE | ID: mdl-33810961
BACKGROUND AND AIMS: Atherosclerotic calcification is a powerful predictor of cardiovascular disease. This study aims to determine whether circulating levels of a local/systemic calcification inhibitor or a marker of bone formation correlate with measures of coronary or extracoronary calcification. METHODS AND RESULTS: Clinical computed tomography (CT) was performed on 64 arterial disease participants undergoing carotid and lower extremity endarterectomy. Coronary artery calcium (CAC) scores and volumes were acquired from the CT scans (n = 42). CAC scores and volumes were used to derive CAC density scores. Micro-CT was performed on excised carotid (n = 36) and lower extremity (n = 31) plaques to quantify the volume and volume fraction of extracoronary calcification. Circulating levels of dephospho-uncarboxylated Matrix Gla Protein (dp-ucMGP), fetuin-A, carboxylated and uncarboxylated osteocalcin (ucOC) were quantified using commercial immunoassays. Carotid participant CAC density scores were moderately negatively correlated with plasma dp-ucMGP (rs = -0.592, P = 0.008). A weak negative association was found between CAC scores and %ucOC for all participants (rs = -0.335, P = 0.040). Another weak negative correlation was observed between fetuin-A and the volume of calcification within excised carotid specimens (rs = -0.366, P = 0.031). Despite substantial differences in coronary and extracoronary calcium measurements, the levels of circulating biomarkers did not vary significantly between carotid and lower extremity subgroups. CONCLUSION: Correlations identified between circulating biomarkers and measures of coronary and extracoronary calcium were not consistent among participant subgroups. Further research is required to determine the association between circulating biomarkers, coronary and extracoronary calcium.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Proteínas de Unión al Calcio / Enfermedades de las Arterias Carótidas / Osteocalcina / Proteínas de la Matriz Extracelular / Extremidad Inferior / Enfermedad Arterial Periférica / Calcificación Vascular / Alfa-2-Glicoproteína-HS Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Proteínas de Unión al Calcio / Enfermedades de las Arterias Carótidas / Osteocalcina / Proteínas de la Matriz Extracelular / Extremidad Inferior / Enfermedad Arterial Periférica / Calcificación Vascular / Alfa-2-Glicoproteína-HS Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos