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Work Shift, Lifestyle Factors, and Subclinical Atherosclerosis in Spanish Male Workers: A Mediation Analysis.
Peñalvo, José L; Mertens, Elly; Muñoz-Cabrejas, Ainara; León-Latre, Montserrat; Jarauta, Estíbaliz; Laclaustra, Martín; Ordovás, José M; Casasnovas, José Antonio; Uzhova, Irina; Moreno-Franco, Belén.
Afiliación
  • Peñalvo JL; Non-Communicable Diseases Unit, Department of Public Health, Institute of Tropical Medicine, 2000 Antwerp, Belgium.
  • Mertens E; Non-Communicable Diseases Unit, Department of Public Health, Institute of Tropical Medicine, 2000 Antwerp, Belgium.
  • Muñoz-Cabrejas A; Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV, 50009 Zaragoza, Spain.
  • León-Latre M; Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV, 50009 Zaragoza, Spain.
  • Jarauta E; Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, 50009 Zaragoza, Spain.
  • Laclaustra M; Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV, 50009 Zaragoza, Spain.
  • Ordovás JM; Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, 50009 Zaragoza, Spain.
  • Casasnovas JA; Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERCV, 50009 Zaragoza, Spain.
  • Uzhova I; Department of Medicine, Psychiatry and Dermatology, University of Zaragoza, 50009 Zaragoza, Spain.
  • Moreno-Franco B; Nutritional Genomics and Epigenomics Group, IMDEA Food, CEI UAM + CSIC, 28049 Madrid, Spain.
Nutrients ; 13(4)2021 Mar 26.
Article en En | MEDLINE | ID: mdl-33810210
(1) Background: Working night shifts has been associated with altered circadian rhythms, lifestyle habits, and cardiometabolic risks. No information on the potential association of working shift and the presence of atherosclerosis is available. The aim of this study was to quantify the association between different work shifts and the presence of subclinical atherosclerosis objectively measured by imaging. (2) Methods: Analyses were conducted on the baseline data of the Aragon Workers Health Study (AWHS) cohort, including information on 2459 middle-aged men. Categories of shift work included central day shift, rotating morning-evening or morning-evening-night shift, and night shift. The presence of atherosclerotic plaques was assessed by 2D ultrasound in the carotid and femoral vascular territories. Multivariable logistic models and mediation analysis were conducted to characterize and quantify the association between study variables. (3) Results: Participants working night or rotating shifts presented an overall worse cardiometabolic risk profile, as well as more detrimental lifestyle habits. Workers in the most intense (morning-evening-night) rotating shift presented higher odds of subclinical atherosclerosis (odds ratio: 1.6; 95% confidence interval: 1.12 to 2.27) compared to workers in the central shift, independently of the presence of lifestyle and metabolic risk factors. A considerable (21%) proportion of this association was found to be mediated by smoking, indicating that altered sleep-wake cycles have a direct relationship with the early presence of atherosclerotic lesions. (4) Conclusions: Work shifts should be factored in during workers health examinations, and when developing effective workplace wellness programs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aterosclerosis / Horario de Trabajo por Turnos / Estilo de Vida Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Nutrients Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aterosclerosis / Horario de Trabajo por Turnos / Estilo de Vida Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Nutrients Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Suiza