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High Levels of Tetrodotoxin (TTX) in Trumpet Shell Charonia lampas from the Portuguese Coast.
Costa, Pedro Reis; Giráldez, Jorge; Rodrigues, Susana Margarida; Leão, José Manuel; Pinto, Estefanía; Soliño, Lucía; Gago-Martínez, Ana.
Afiliación
  • Costa PR; IPMA-Portuguese Institute of the Sea and Atmosphere, Av. Brasília, 1449-006 Lisbon, Portugal.
  • Giráldez J; CCMAR-Center of Marine Sciences, Campus of Gambelas, University of Algarve, 8005-139 Faro, Portugal.
  • Rodrigues SM; Biomedical Research Center (CINBIO), Department of Analytical and Food Chemistry, Campus Universitario de Vigo, University of Vigo, 36310 Vigo, Spain.
  • Leão JM; IPMA-Portuguese Institute of the Sea and Atmosphere, Av. Brasília, 1449-006 Lisbon, Portugal.
  • Pinto E; Biomedical Research Center (CINBIO), Department of Analytical and Food Chemistry, Campus Universitario de Vigo, University of Vigo, 36310 Vigo, Spain.
  • Soliño L; IPMA-Portuguese Institute of the Sea and Atmosphere, Av. Brasília, 1449-006 Lisbon, Portugal.
  • Gago-Martínez A; IPMA-Portuguese Institute of the Sea and Atmosphere, Av. Brasília, 1449-006 Lisbon, Portugal.
Toxins (Basel) ; 13(4)2021 03 31.
Article en En | MEDLINE | ID: mdl-33807311
Tetrodotoxin (TTX) is a potent neurotoxin, considered an emerging toxin in Europe where recently a safety limit of 44 µg TTX kg-1 was recommended by authorities. In this study, three specimens of the large gastropod trumpet shell Charonia lampas bought in a market in south Portugal were analyzed using a neuroblastoma cell (N2a) based assay and by LC-MS/MS. N2a toxicity was observed in the viscera of two individuals analyzed and LC-MS/MS showed very high concentrations of TTX (42.1 mg kg-1) and 4,9-anhydroTTX (56.3 mg kg-1). A third compound with m/z 318 and structurally related with TTX was observed. In the edible portion, i.e., the muscle, toxin levels were below the EFSA recommended limit. This study shows that trumpet shell marine snails are seafood species that may reach the markets containing low TTX levels in the edible portion but containing very high levels of TTX in non-edible portion raising concerns regarding food safety if a proper evisceration is not carried out by consumers. These results highlight the need for better understanding TTX variability in this gastropod species, which is critical to developing a proper legal framework for resources management ensuring seafood safety, and the introduction of these gastropods in the markets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tetrodotoxina / Contaminación de Alimentos / Alimentos Marinos / Gastrópodos Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Toxins (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tetrodotoxina / Contaminación de Alimentos / Alimentos Marinos / Gastrópodos Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Toxins (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Suiza