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Exaggerated Cardiac Contractile Response to Hypoxia in Adults Born Preterm.
Barton, Gregory P; Corrado, Philip A; Francois, Christopher J; Chesler, Naomi C; Eldridge, Marlowe W; Wieben, Oliver; Goss, Kara N.
Afiliación
  • Barton GP; Department of Medical Physics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53792, USA.
  • Corrado PA; Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53792, USA.
  • Francois CJ; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Chesler NC; Department of Medical Physics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53792, USA.
  • Eldridge MW; Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53792, USA.
  • Wieben O; Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53792, USA.
  • Goss KN; Department of Biomedical Engineering, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53792, USA.
J Clin Med ; 10(6)2021 Mar 10.
Article en En | MEDLINE | ID: mdl-33802149
Individuals born prematurely have smaller hearts, cardiac limitations to exercise, and increased overall cardiometabolic risk. The cardiac effects of acute hypoxia exposure as another physiologic stressor remain under explored. The purpose of this study was to determine the effects of hypoxia on ventricular function in adults born preterm. Adults born moderately to extremely preterm (≤32 weeks gestation or <1500 g, N = 32) and born at term (N = 18) underwent cardiac magnetic resonance imaging under normoxic (21% O2) and hypoxic (12% O2) conditions to assess cardiovascular function. In normoxia, cardiac function parameters were similar between groups. During hypoxia, the right ventricular (RV) contractile response was significantly greater in participants born premature, demonstrated by greater increases in RV ejection fraction (EF) (p = 0.002), ventricular-vascular coupling (VVC) (p = 0.004), and strain (p < 0.0001) measures compared to term-born participants, respectively. Left ventricular contractile reserve was similar to term-born participants. Adults born preterm exhibit an exaggerated contractile response to acute hypoxia, particularly in the RV. This suggests that adults born preterm may have contractile reserve, despite the lack of volume reserve identified in previous exercise studies. However, this exaggerated and hyper-adapted response may also increase their risk for late RV failure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza