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Evaluation of Antioxidant and Enzyme Inhibition Properties of Croton hirtus L'Hér. Extracts Obtained with Different Solvents.
Dall'Acqua, Stefano; Sinan, Kouadio Ibrahime; Sut, Stefania; Ferrarese, Irene; Etienne, Ouattara Katinan; Mahomoodally, Mohamad Fawzi; Lobine, Devina; Zengin, Gokhan.
Afiliación
  • Dall'Acqua S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.
  • Sinan KI; Department of Biology, Science Faculty, Selcuk University, Campus, 42130 Konya, Turkey.
  • Sut S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.
  • Ferrarese I; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.
  • Etienne OK; Laboratoire de Botanique, UFR Biosciences, Université Félix Houphouët-Boigny, 00225 Abidjan, Côte d'Ivoire.
  • Mahomoodally MF; Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, 230 Réduit, Mauritius.
  • Lobine D; Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, 230 Réduit, Mauritius.
  • Zengin G; Department of Biology, Science Faculty, Selcuk University, Campus, 42130 Konya, Turkey.
Molecules ; 26(7)2021 Mar 28.
Article en En | MEDLINE | ID: mdl-33800622
Croton hirtus L'Hér methanol extract was studied by NMR and two different LC-DAD-MSn using electrospray (ESI) and atmospheric pressure chemical ionization (APCI) sources to obtain a quali-quantitative fingerprint. Forty different phytochemicals were identified, and twenty of them were quantified, whereas the main constituents were dihydro α ionol-O-[arabinosil(1-6) glucoside] (133 mg/g), dihydro ß ionol-O-[arabinosil(1-6) glucoside] (80 mg/g), ß-sitosterol (49 mg/g), and isorhamnetin-3-O-rutinoside (26 mg/g). C. hirtus was extracted with different solvents-namely, water, methanol, dichloromethane, and ethyl acetate-and the extracts were assayed using different in vitro tests. The methanolic extracts presented the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRAP) values. All the tested extracts exhibited inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with a higher activity observed for dichloromethane (AChE: 5.03 and BChE: 16.41 mgGALAE/g), while the methanolic extract showed highest impact against tyrosinase (49.83 mgKAE/g). Taken together, these findings suggest C. hirtus as a novel source of bioactive phytochemicals with potential for commercial development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fitosteroles / Terpenos / Inhibidores de la Colinesterasa / Croton / Fitoquímicos / Glucósidos / Antioxidantes Tipo de estudio: Prognostic_studies Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fitosteroles / Terpenos / Inhibidores de la Colinesterasa / Croton / Fitoquímicos / Glucósidos / Antioxidantes Tipo de estudio: Prognostic_studies Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza