Mesenchymal Stem Cell-Based Therapy for Retinal Degenerative Diseases: Experimental Models and Clinical Trials.

Holan, Vladimir; Palacka, Katerina; Hermankova, Barbora

Holan, Vladimir; Palacka, Katerina; Hermankova, Barbora.

Afiliación

Holan V; Department of Nanotoxicology and Molecular Epidemiology, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Palacka K; Department of Cell Biology, Faculty of Science, Charles University, 12843 Prague, Czech Republic.
Hermankova B; Department of Nanotoxicology and Molecular Epidemiology, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.

Cells ; 10(3)2021 03 07.

Article en En | MEDLINE | ID: mdl-33799995

RESUMEN

Retinal degenerative diseases, such as age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy or glaucoma, represent the main causes of a decreased quality of vision or even blindness worldwide. However, despite considerable efforts, the treatment possibilities for these disorders remain very limited. A perspective is offered by cell therapy using mesenchymal stem cells (MSCs). These cells can be obtained from the bone marrow or adipose tissue of a particular patient, expanded in vitro and used as the autologous cells. MSCs possess potent immunoregulatory properties and can inhibit a harmful inflammatory reaction in the diseased retina. By the production of numerous growth and neurotrophic factors, they support the survival and growth of retinal cells. In addition, MSCs can protect retinal cells by antiapoptotic properties and could contribute to the regeneration of the diseased retina by their ability to differentiate into various cell types, including the cells of the retina. All of these properties indicate the potential of MSCs for the therapy of diseased retinas. This view is supported by the recent results of numerous experimental studies in different preclinical models. Here we provide an overview of the therapeutic properties of MSCs, and their use in experimental models of retinal diseases and in clinical trials.

Asunto(s)

Tratamiento Basado en Trasplante de Células y Tejidos/métodos; Retinopatía Diabética/terapia; Glaucoma/terapia; Degeneración Macular/terapia; Trasplante de Células Madre Mesenquimatosas/métodos; Células Madre Mesenquimatosas/citología; Retinitis Pigmentosa/terapia; Tejido Adiposo/citología; Tejido Adiposo/metabolismo; Animales; Células de la Médula Ósea/citología; Células de la Médula Ósea/metabolismo; Diferenciación Celular; Ensayos Clínicos como Asunto; Retinopatía Diabética/genética; Retinopatía Diabética/metabolismo; Retinopatía Diabética/patología; Modelos Animales de Enfermedad; Glaucoma/genética; Glaucoma/metabolismo; Glaucoma/patología; Humanos; Péptidos y Proteínas de Señalización Intercelular/genética; Péptidos y Proteínas de Señalización Intercelular/metabolismo; Degeneración Macular/genética; Degeneración Macular/metabolismo; Degeneración Macular/patología; Células Madre Mesenquimatosas/metabolismo; Factores de Crecimiento Nervioso/genética; Factores de Crecimiento Nervioso/metabolismo; Retina/metabolismo; Retina/patología; Retinitis Pigmentosa/genética; Retinitis Pigmentosa/metabolismo; Retinitis Pigmentosa/patología; Trasplante Autólogo

Palabras clave

clinical trials; experimental models; mesenchymal stem cells; retinal degenerative diseases; stem cell therapy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retinitis Pigmentosa / Glaucoma / Trasplante de Células Madre Mesenquimatosas / Retinopatía Diabética / Células Madre Mesenquimatosas / Tratamiento Basado en Trasplante de Células y Tejidos / Degeneración Macular Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Suiza

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