Molecular Mechanisms for Bacterial Potassium Homeostasis.
J Mol Biol
; 433(16): 166968, 2021 08 06.
Article
en En
| MEDLINE
| ID: mdl-33798529
Potassium ion homeostasis is essential for bacterial survival, playing roles in osmoregulation, pH homeostasis, regulation of protein synthesis, enzyme activation, membrane potential adjustment and electrical signaling. To accomplish such diverse physiological tasks, it is not surprising that a single bacterium typically encodes several potassium uptake and release systems. To understand the role each individual protein fulfills and how these proteins work in concert, it is important to identify the molecular details of their function. One needs to understand whether the systems transport ions actively or passively, and what mechanisms or ligands lead to the activation or inactivation of individual systems. Combining mechanistic information with knowledge about the physiology under different stress situations, such as osmostress, pH stress or nutrient limitation, one can identify the task of each system and deduce how they are coordinated with each other. By reviewing the general principles of bacterial membrane physiology and describing the molecular architecture and function of several bacterial K+-transporting systems, we aim to provide a framework for microbiologists studying bacterial potassium homeostasis and the many K+-translocating systems that are still poorly understood.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Potasio
/
Bacterias
/
Fenómenos Fisiológicos Bacterianos
/
Homeostasis
Idioma:
En
Revista:
J Mol Biol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Países Bajos