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Mast Cells and Proteins Related to Myofibroblast Differentiation (PAR-2, IL-6, and TGFß1) in Salivary Cancers: A Preliminary Study.
Ismerim, Adna B; de Oliveira Araújo, Iguaracyra B; de Aquino Xavier, Flávia C; Rocha, Clarissa A G; Macedo, Cláudia L; Cangussu, Maria C T; Freitas, Valéria S; Della Coletta, Ricardo; Cury, Patrícia R; Santos, Jean N.
Afiliación
  • Ismerim AB; Department of Health, School of Dentistry, Southwestern State University of Bahia, Jequié.
  • de Oliveira Araújo IB; Department of Pathology, Aristides Maltez Hospital.
  • de Aquino Xavier FC; Laboratory of Surgical Pathology.
  • Rocha CAG; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador.
  • Macedo CL; Micro Laboratory of Surgical Pathology, Vitória da Conquista.
  • Cangussu MCT; Department of Dental Public Health, School of Dentistry, Federal University of Bahia.
  • Freitas VS; Department of Health, School of Dentistry, State University of Feira de Santana, Feira de Santana.
  • Della Coletta R; Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil.
  • Cury PR; Department of Periodontic, School of Dentistry, State University of Feira de Santana, Feira de Santana, Bahia.
  • Santos JN; Laboratory of Surgical Pathology.
Appl Immunohistochem Mol Morphol ; 29(7): e57-e67, 2021 08 01.
Article en En | MEDLINE | ID: mdl-33797435
Salivary gland neoplasms represent an important group of cancers in the head and neck and myoepithelial cells play a key role on the development these tumors. This study evaluated the distribution of mast cells and related proteins (PAR-2, TGFß1, IL-6) to the myofibroblastic differentiation in malignant tumors of salivary glands with and without myoepithelial differentiation. Immunohistochemical assessement for tryptase mast cells, SMA, PAR-2, TGFß1, IL-6 was performed in 10 cases of polymorphous low-grade adenocarcinoma, 14 cases of mucoepidermoid carcinoma (MEC) and 10 cases of adenoid cystic carcinoma. When the density of mast cells were compared between tumors, their density was significantly higher in MEC (P=0.08). Tumors with high expression of PAR-2 (79.4%) exhibited a high density of mast cells. Myofibroblasts were more frequent in malignant tumors with low expression (<50%) of cell masts. Individual analysis of the tumors showed no significant difference between the expression of PAR-2, IL-6, TGFß1, and myofibroblasts. When the density of mast cells, myofibroblasts and the expression of PAR-2 protein, IL-6, and TGFß1 were compared, it was no statistically significant difference between tumors with and without myoepithelial differentiation. The results of present study suggest a possible participation of mast cells and especially of PAR-2 in the development and progression of malignant salivary cancers, regardless of myoepithelial content.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Glándulas Salivales / Diferenciación Celular / Interleucina-6 / Receptor PAR-2 / Factor de Crecimiento Transformador beta1 / Miofibroblastos / Mastocitos / Proteínas de Neoplasias Límite: Humans Idioma: En Revista: Appl Immunohistochem Mol Morphol Asunto de la revista: BIOLOGIA MOLECULAR / HISTOCITOQUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Glándulas Salivales / Diferenciación Celular / Interleucina-6 / Receptor PAR-2 / Factor de Crecimiento Transformador beta1 / Miofibroblastos / Mastocitos / Proteínas de Neoplasias Límite: Humans Idioma: En Revista: Appl Immunohistochem Mol Morphol Asunto de la revista: BIOLOGIA MOLECULAR / HISTOCITOQUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos