2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways.

Luo, Mengxin; Shi, Xiaoxia; Guo, Qi; Li, Shuangyue; Zhang, Qing; Sun, Xiuyan; Piao, Fengyuan

Luo, Mengxin; Shi, Xiaoxia; Guo, Qi; Li, Shuangyue; Zhang, Qing; Sun, Xiuyan; Piao, Fengyuan.

Afiliación

Luo M; Department of Occupational and Environmental Health, school of public health, Dalian Medical University, Dalian 116044, China.
Shi X; Department of Occupational and Environmental Health, school of public health, Dalian Medical University, Dalian 116044, China.
Guo Q; Department of Environment Hygiene Division, Dalian Center for Disease Control and Prevention, Dalian 116021, China.
Li S; Department of Occupational and Environmental Health, school of public health, Dalian Medical University, Dalian 116044, China.
Zhang Q; Department of Integrative Laboratory, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China.
Sun X; Department of Integrative Laboratory, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China.
Piao F; Department of Integrative Laboratory, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China.

Biosci Rep ; 41(4)2021 04 30.

Article en En | MEDLINE | ID: mdl-33792642

Asunto(s)

Apoptosis; Hexanonas/farmacología; Factores de Crecimiento Nervioso/metabolismo; Neuronas/metabolismo; Neurotoxinas/farmacología; Precursores de Proteínas/metabolismo; Médula Espinal/efectos de los fármacos; Animales; Línea Celular Tumoral; Hexanonas/toxicidad; MAP Quinasa Quinasa 4/metabolismo; Masculino; Proteínas del Tejido Nervioso/metabolismo; Neuronas/efectos de los fármacos; Neurotoxinas/toxicidad; Ratas; Ratas Sprague-Dawley; Receptores de Factores de Crecimiento/metabolismo; Transducción de Señal; Médula Espinal/citología; Médula Espinal/metabolismo

Palabras clave

2,5-Hexanedione; Apoptosis; JNK pathway; Neurotoxicity; ProNGF

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Precursores de Proteínas / Médula Espinal / Apoptosis / Hexanonas / Factores de Crecimiento Nervioso / Neuronas / Neurotoxinas Límite: Animals Idioma: En Revista: Biosci Rep Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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