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Epithelial-Mesenchymal Transition in the Resistance to Somatostatin Receptor Ligands in Acromegaly.
Gil, Joan; Jordà, Mireia; Soldevila, Berta; Puig-Domingo, Manel.
Afiliación
  • Gil J; Endocrine Tumours Lab, Program of Predictive and Personalized Medicine of Cancer (PMPPC), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
  • Jordà M; Endocrine Tumours Lab, Program of Predictive and Personalized Medicine of Cancer (PMPPC), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
  • Soldevila B; Department of Endocrinology and Nutrition, Germans Trias i Pujol University Hospital, Badalona, Spain.
  • Puig-Domingo M; Endocrine Tumours Lab, Program of Predictive and Personalized Medicine of Cancer (PMPPC), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
Front Endocrinol (Lausanne) ; 12: 646210, 2021.
Article en En | MEDLINE | ID: mdl-33790868
Epithelial-mesenchymal transition (EMT) is a dynamic process by which epithelial cells loss their phenotype and acquire mesenchymal traits, including increased migratory and invasive capacities. EMT is involved in physiological processes, such as embryogenesis and wound healing, and in pathological processes such as cancer, playing a pivotal role in tumor progression and metastasis. Pituitary tumors, although typically benign, can be locally invasive. Different studies have shown the association of EMT with increased tumor size and invasion in pituitary tumors, and in particular with a poor response to Somatostatin Receptor Ligands (SRLs) treatment in GH-producing pituitary tumors, the main cause of acromegaly. This review will summarize the current knowledge regarding EMT and SRLs resistance in acromegaly and, based on this relation, will suggest new biomarkers and possible therapies to SRLs resistant tumors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acromegalia / Resistencia a Medicamentos / Neoplasias de las Glándulas Endocrinas / Receptores de Somatostatina / Adenoma Hipofisario Secretor de Hormona del Crecimiento / Transición Epitelial-Mesenquimal / Ligandos Tipo de estudio: Etiology_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acromegalia / Resistencia a Medicamentos / Neoplasias de las Glándulas Endocrinas / Receptores de Somatostatina / Adenoma Hipofisario Secretor de Hormona del Crecimiento / Transición Epitelial-Mesenquimal / Ligandos Tipo de estudio: Etiology_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza