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Cytotoxicity and inflammatory effects in human bronchial epithelial cells induced by polycyclic aromatic hydrocarbons mixture.
Wang, Hong; Liu, Jinren; Kong, Qingbo; Li, Liang; Gao, Junhong; Fang, Le; Liu, Zhiyong; Fan, Xiaolin; Li, Cunzhi; Lu, Qing; Qian, Airong.
Afiliación
  • Wang H; Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Lab for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytech
  • Liu J; Biological Effects and Technology Division, Institute for Hygiene of Ordnance Industry, Xi'an, China.
  • Kong Q; Biological Effects and Technology Division, Institute for Hygiene of Ordnance Industry, Xi'an, China.
  • Li L; Biological Effects and Technology Division, Institute for Hygiene of Ordnance Industry, Xi'an, China.
  • Gao J; Biological Effects and Technology Division, Institute for Hygiene of Ordnance Industry, Xi'an, China.
  • Fang L; Biological Effects and Technology Division, Institute for Hygiene of Ordnance Industry, Xi'an, China.
  • Liu Z; Department of Clinical Laboratory, 521 Hospital of Ordnance Industry, Xi'an, China.
  • Fan X; Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Lab for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytech
  • Li C; Biological Effects and Technology Division, Institute for Hygiene of Ordnance Industry, Xi'an, China.
  • Lu Q; Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Lab for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytech
  • Qian A; Biological Effects and Technology Division, Institute for Hygiene of Ordnance Industry, Xi'an, China.
J Appl Toxicol ; 41(11): 1803-1815, 2021 11.
Article en En | MEDLINE | ID: mdl-33782999
Polycyclic aromatic hydrocarbons (PAHs) are the most common contaminants in the air pollutants. Inhalation exposure to PAHs could increase the risk of respiratory disease, cardiovascular disease and even cancer. However, the biotoxicity of multi-component PAHs from atmospheric pollutants has been poorly studies. The main topic of this study was to investigate the PAHs mixture, which derived from atmospheric pollutants, induced toxic effects and inflammatory effects on human bronchial epithelial cells in vitro. The results showed that PAHs mixture could decrease the cell viability, increase the apoptosis rate, and induce cell cycle arrest at S-phase. Furthermore, the expression of inflammatory factors IL-1ß and IL-6 were increased and NF-κB signaling pathway was activated in PAHs mixture-treated cells. The findings of this study indicate that PAHs mixture-induced cytotoxicity and inflammation may be related to intracellular ROS generation and to the activated NF-κB signaling pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocarburos Policíclicos Aromáticos / Bronquios / Citotoxinas / Contaminantes Atmosféricos / Células Epiteliales Límite: Humans Idioma: En Revista: J Appl Toxicol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocarburos Policíclicos Aromáticos / Bronquios / Citotoxinas / Contaminantes Atmosféricos / Células Epiteliales Límite: Humans Idioma: En Revista: J Appl Toxicol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido