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Neurobiological Pathways Linking Acute Mental Stress to Impairments in Executive Function in Individuals with Coronary Artery Disease.
Moazzami, Kasra; Wittbrodt, Matthew T; Lima, Bruno B; Kim, Jeong Hwan; Almuwaqqat, Zakaria; Shah, Amit J; Hajjar, Ihab; Goldstein, Felicia C; Levey, Allan I; Nye, Jonathon A; Bremner, J Douglas; Vaccarino, Viola; Quyyumi, Arshed A.
Afiliación
  • Moazzami K; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Wittbrodt MT; Emory Clinical Cardiovascular Research Institute, Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
  • Lima BB; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • Kim JH; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Almuwaqqat Z; Emory Clinical Cardiovascular Research Institute, Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
  • Shah AJ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Hajjar I; Emory Clinical Cardiovascular Research Institute, Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
  • Goldstein FC; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Levey AI; Emory Clinical Cardiovascular Research Institute, Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
  • Nye JA; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Bremner JD; Emory Clinical Cardiovascular Research Institute, Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
  • Vaccarino V; Atlanta VA Medical Center, Decatur, GA, USA.
  • Quyyumi AA; Department of Neurology, Emory University School of Medicine, Emory University, Atlanta, GA, USA.
J Alzheimers Dis Rep ; 5(1): 99-109, 2021 Feb 02.
Article en En | MEDLINE | ID: mdl-33782663
BACKGROUND: Individuals with coronary artery disease (CAD) have worse executive function compared to the general population but the mechanisms are unknown. OBJECTIVE: To investigate the role of acute mental stress (MS) on the executive function of patients with CAD. METHODS: Participants with stable CAD underwent acute MS testing with simultaneous peripheral vascular function measurements and brain imaging using high resolution-positron emission tomography. Digital pulse wave amplitude was continuously measured using peripheral artery tonometry (PAT, Itamar Inc). Stress/rest PAT ratio (sPAT) of pulse wave amplitude during MS/baseline was calculated as a measure of microvascular constriction during MS. Plasma levels of catecholamine and interleukin-6 were assessed at baseline and after MS. Executive function was assessed both at baseline and at 2 years follow-up using the Trail Making Test parts A and B. RESULTS: We studied 389 individuals with brain data available for 148 participants. Of this population follow-up cognitive assessments were performed in 226 individuals (121 with brain imaging). After multivariable adjustment for baseline demographics, risk factors, and medication use, a lower sPAT, indicating greater vasoconstriction, a higher inferior frontal lobe activation with MS, and increases in norepinephrine and IL-6 levels with MS were all independently associated with greater time to complete Trail B test.-38.4pt. CONCLUSION: In response to acute MS, greater peripheral vasoconstriction, higher inferior frontal lobe brain activation, and increases in the levels of norepinephrine and IL-6 are associated with worse executive function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Alzheimers Dis Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Alzheimers Dis Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos