ADIPOQ, adiponectin; AKT; ALD, alcoholic liver disease; ALDH2, aldehyde dehydrogenase 2; ALT, alanine aminotransferase; AMPK, adenosine 5'-monophosphate (AMP)-activated protein kinase; AST, aspartate aminotransferase; ATGL, adipose triglyceride lipase; Alcoholic liver disease; CPT1, carnitine palmitoyltransferase I; CYP2E1, cytochrome P450 2E1; FDA, U.S. Food and Drug Administration; FFA, free fatty acids; GRB14, growth factor receptor-bound protein 14; GSK3ß; GSK3ß, glycogen synthase kinase 3 beta; GTT, glucose tolerance test; HSL, hormone sensitive lipase; IGF-1, insulin-like growth factors-1; IL, interleukin; INSR, insulin receptor; IRS, insulin receptor substrate; IRS-1; IRTK, insulin receptor tyrosine kinase; Insulin receptor; Insulin resistance; LDLR, low-density lipoprotein receptor; LRP6, low-density lipoprotein receptor related protein 6; MTT, 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide; NAC, N-acetyl-cysteine; NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD activity score; NF-κB, nuclear factor kappa B; NIAAA, National Institute on Alcohol Abuse and Alcoholism; NRF2, nuclear factor erythroid 2-related factor 2; ORF, open reading frame; PA, palmitate acid; PPARα, peroxisome proliferator-activated receptor alpha; RER, respiratory exchange ratio; S-Allylmercaptocysteine; SAMC, S-allylmercaptocysteine; SPR, surface plasmon resonance; SREBP-1c, sterol regulatory element-binding protein 1c; Safety; TC, total cholesterol; TCF/LEF, T-cell factor/lymphoid enhancer factor; TG, triglyceride; TNF, tumor necrosis factor; TSA, thermal shift assay; WAT, white adipose tissues; WT, wild-type