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FGF23, alpha-Klotho and vitamin D mediated calcium-phosphate metabolism in haemodialysis patients.
Pasaoglu, Ozge Tugce; Senelmis, Ayse; Helvaci, Ozant; Derici, Ulver; Pasaoglu, Hatice.
Afiliación
  • Pasaoglu OT; Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkey.
  • Senelmis A; Gazi University, Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
  • Helvaci O; Gazi University, Faculty of Medicine, Department of Internal Medicine, Section of Nephrology, Ankara, Turkey.
  • Derici U; Gazi University, Faculty of Medicine, Department of Internal Medicine, Section of Nephrology, Ankara, Turkey.
  • Pasaoglu H; Gazi University, Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
J Med Biochem ; 40(2): 160-166, 2021 Mar 12.
Article en En | MEDLINE | ID: mdl-33776565
BACKGROUND: Klotho is a prote˝in that acts as a co-receptor for FGF23. FGF23-Klotho axis has great importance regarding the regulation of mineral metabolism by kidneys. In this study, we analysed FGF23, Klotho, 1,25-dihydroxyvitamin D3, 25-hydroxyvitamin D, parathormone, Calcium and Phosphate levels of haemodialysis patients in order to investigate the nature of the mineral metabolism disruption in chronic kidney diseases. METHODS: Sixty haemodialysis patients and 34 healthy controls were included in the study. Serum iFGF, cFGF, and soluble Klotho were analysed using ELISA kits. Moreover, 1,25-dihydroxyvitamin D3 was determined using LCMS/MS. Calcium, phosphate, iPTH and 25-hydroxyvitamin D were measured using autoanalyzers. RESULTS: In haemodialysis patients, iFGF23, cFGF23, iPTH and P levels were significantly higher, and 1,25-dihydroxyvitamin D3, Klotho and Ca levels were significantly lower compared with the control group. There was no significant difference in the 25-hydroxyvitamin D levels. CONCLUSIONS: Our study showed that lack of sufficient amounts of Klotho is crucial for mineral metabolism disruptions seen as a complication of chronic kidney diseases. Despite the high levels of the hormone, FGF23 is unable to accomplish its function properly, likely due to deteriorated kidney function in haemodialysis patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Med Biochem Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Serbia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Med Biochem Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Serbia