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Successful Rituximab Treatment in Thrombotic Thrombocytopenic Purpura Patients Complicated by Other Autoimmune Disorders: Two Case Reports.
Watanabe, Aya; Shiseki, Masayuki; Oishi, Megumi; Kobayashi, Maya; Oshima, Shoko; Osanai, Satoko; Ryuzaki, Michiko; Izuka, Yuki; Tanaka, Norina; Ishiyama, Midori; Shinohara, Akihito; Kazama, Hiroshi; Hagiwara, Shotaro; Yoshinaga, Kentaro; Tanaka, Junji.
Afiliación
  • Watanabe A; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Shiseki M; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Oishi M; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Kobayashi M; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Oshima S; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Osanai S; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Ryuzaki M; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Izuka Y; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Tanaka N; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Ishiyama M; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Shinohara A; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Kazama H; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Hagiwara S; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Yoshinaga K; Department of Hematology, Tokyo Women's Medical University, Japan.
  • Tanaka J; Department of Hematology, Tokyo Women's Medical University, Japan.
Intern Med ; 60(17): 2859-2862, 2021 Sep 01.
Article en En | MEDLINE | ID: mdl-33775998
We herein report two cases of thrombotic thrombocytopenic purpura (TTP) complicated by other autoimmune disorders, autoimmune hepatitis and immune thrombocytopenia, respectively. In both cases, corticosteroids were continuously administered for the treatment of preceding autoimmune disorders. However, a sufficient objective response for TTP was not obtained by plasma exchange and corticosteroid treatment. Once a week rituximab (375 mg/m2) treatment for 4 times was initiated within 2 weeks from the diagnosis. Both patients achieved a sufficient response, and have never had any recurrence as of the last follow-up dates. The early introduction of rituximab could be an effective treatment option in TTP patients complicated with other autoimmune disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Púrpura Trombocitopénica Trombótica / Púrpura Trombocitopénica Idiopática Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Púrpura Trombocitopénica Trombótica / Púrpura Trombocitopénica Idiopática Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón