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Efficacy and safety of tetracyclines for pemphigoid: a systematic review and meta-analysis.
Jin, Xin-Xing; Wang, Xue; Shan, Ying; Li, Si-Zhe; Xu, Qun; Jin, Hong-Zhong; Zuo, Ya-Gang.
Afiliación
  • Jin XX; Department of Dermatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1, shuaifuyuan hutong, Dongcheng district, Beijing, 100
  • Wang X; Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
  • Shan Y; Department of Dermatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1, shuaifuyuan hutong, Dongcheng district, Beijing, 100
  • Li SZ; Department of Dermatology, Graduate student of Hebei North University, Hebei, 075051, China.
  • Xu Q; Department of Dermatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1, shuaifuyuan hutong, Dongcheng district, Beijing, 100
  • Jin HZ; Department of Epidemiology and Biostatistics, School of Basic Medicine Peking Union Medical College, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, 100005, China.
  • Zuo YG; Department of Dermatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1, shuaifuyuan hutong, Dongcheng district, Beijing, 100
Arch Dermatol Res ; 314(2): 191-201, 2022 Mar.
Article en En | MEDLINE | ID: mdl-33774726
The aim of this review was to evaluate the efficacy and safety of tetracyclines for treatment of pemphigoid. We searched PubMed, EMBASE, Ovid, Web of Science, and the Cochrane Library for studies involving pemphigoid patients treated with tetracyclines published in English before 29 February 2020. References of included studies were also screened to widen the scope of the literature search. Data regarding predefined clinical outcomes of 341 patients from 77 studies were extracted and analyzed. A meta-analysis was conducted on the basis of 4 studies including 2 randomized controlled trials and 2 comparative studies. The patients had a mean age of 74.60 ± 13.18 years, 45.4% were males, and 54.6% were females. There were 185 patients with mild-to-moderate and 143 patients with severe disease. The average initial doses were 1.62 ± 0.39 g/day for tetracycline, 0.20 ± 0.01 g/day for doxycycline, and 0.11 ± 0.05 g/day for minocycline. The average time on tetracyclines was 3.74 ± 5.99 months, and 261 (81.3%) patients reported partial or complete remission. Relapses occurred in 72 (28.3%) cases. Adverse effects were experienced by 130 (41.9%) patients. The pooled ORs for short-term effectiveness, relapse, adverse effects, and 1-year survival in patients treated with oral tetracyclines vs. systemic corticosteroids were 0.40 (95% CI, 0.22-0.76), 0.69 (95% CI, 0.44-1.10), 0.47 (95% CI, 0.27-0.82) and 2.02 (95% CI, 1.16-3.50), respectively. Compared to doxycycline and minocycline, tetracycline was significantly associated with better treatment outcomes and fewer adverse effects (p < 0.05). This review revealed tetracyclines' efficacy and safety in pemphigoid treatment and may offer support for clinical use of tetracyclines in pemphigoid.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tetraciclinas / Penfigoide Ampolloso / Antibacterianos Tipo de estudio: Clinical_trials / Systematic_reviews Límite: Humans Idioma: En Revista: Arch Dermatol Res Año: 2022 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tetraciclinas / Penfigoide Ampolloso / Antibacterianos Tipo de estudio: Clinical_trials / Systematic_reviews Límite: Humans Idioma: En Revista: Arch Dermatol Res Año: 2022 Tipo del documento: Article Pais de publicación: Alemania