Your browser doesn't support javascript.
loading
Hydrolysis Kinetics of a Novel 3,4-Dichloroisothiazole Plant-Activator Candidate LY5-24-2 by UPLC-Q-TOF.
Song, Shuangyu; Qiao, Chengkui; Han, Lijun; Xie, Hanzhong; Bi, Yingying; Qin, Fayi; Wu, Qifan; Li, Yuedong; Fan, Zhijin.
Afiliación
  • Song S; College of Science, China Agricultural University, Beijing, 100193, People's Republic of China.
  • Qiao C; Zhengzhou Fruit Research Institute of Chinese Academy of Agricultural Sciences, Zhengzhou, 450009, People's Republic of China.
  • Han L; College of Science, China Agricultural University, Beijing, 100193, People's Republic of China. hanlijun2000@163.com.
  • Xie H; Zhengzhou Fruit Research Institute of Chinese Academy of Agricultural Sciences, Zhengzhou, 450009, People's Republic of China. xiehanzhong@caas.cn.
  • Bi Y; College of Science, China Agricultural University, Beijing, 100193, People's Republic of China.
  • Qin F; College of Science, China Agricultural University, Beijing, 100193, People's Republic of China.
  • Wu Q; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, People's Republic of China.
  • Li Y; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, People's Republic of China.
  • Fan Z; State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, People's Republic of China. fanzj@nankai.edu.cn.
Bull Environ Contam Toxicol ; 106(6): 1009-1016, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33772599
Hydrolysis characteristics of a novel 3,4-dichloroisothiazole based fungicide with activating plant defense responses as a candidate plant-activator LY5-24-2 were investigated under different conditions (pH and temperature) using ultra-performance liquid chromatography (UPLC) and quadrupole Time-of-Flight (Q-TOF). The hydrolysis case complied with the first-order kinetic model, with half-lives ranging from 4.8 h to 3.2 days at pH 4, 7, 9 and temperature at 25 and 50℃. One of the hydrolysis metabolite 3,4-dichloroisothiazole-5-carboxylic acid (metabolite 1, M1) was determined and quantified using authentic standard. The other hydrolysate 3-chloro-5-(trifluoromethyl) pyridin-2-amine (metabolite 2, M2) was determined and identified according to accurate mass information, fragmentation patterns and principle component analysis (PCA). By utilizing high-resolution mass spectrometry and multivariate statistical analysis, hydrolysis dynamic of the metabolites was characterized and figured out. This research provided a non-target screening method to analyze hydrolysis metabolites of a new plant-activator and to find its degradation products in aqueous solution.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatografía Líquida de Alta Presión Tipo de estudio: Prognostic_studies Idioma: En Revista: Bull Environ Contam Toxicol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatografía Líquida de Alta Presión Tipo de estudio: Prognostic_studies Idioma: En Revista: Bull Environ Contam Toxicol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos