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Reaction Time Intraindividual Variability Reveals Inhibitory Deficits in Single- and Multiple-Domain Amnestic Mild Cognitive Impairment.
Chow, Ricky; Rabi, Rahel; Paracha, Shahier; Vasquez, Brandon P; Hasher, Lynn; Alain, Claude; Anderson, Nicole D.
Afiliación
  • Chow R; Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada.
  • Rabi R; Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada.
  • Paracha S; Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada.
  • Vasquez BP; Neuropsychology & Cognitive Health, Baycrest Centre, Toronto, Ontario, Canada.
  • Hasher L; Department of Occupational Science & Occupational Therapy, University of Toronto, Ontario, Canada.
  • Alain C; Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada.
  • Anderson ND; Department of Psychology, University of Toronto, Ontario, Canada.
J Gerontol B Psychol Sci Soc Sci ; 77(1): 71-83, 2022 01 12.
Article en En | MEDLINE | ID: mdl-33770153
OBJECTIVES: Amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer's disease and other dementias, is characterized by episodic memory impairment. Recent evidence has shown inhibitory control deficits in aMCI, but the extent of these deficits across inhibitory domains (i.e., response inhibition and interference control) and aMCI subtypes (i.e., single vs multiple domain) remains unclear. Few studies have included reaction time intraindividual variability (RT IIV) in these efforts. The aim of this study was to compare response inhibition and interference control between aMCI subtypes using measures of accuracy, mean RT, and RT IIV. METHODS: We report data from 34 individuals with single-domain aMCI (sdaMCI, 66-86 years), 20 individuals with multiple-domain aMCI (mdaMCI, 68-88 years), and 52 healthy controls (HC, 64-88 years) who completed tasks of response inhibition (Go-NoGo) and interference control (Flanker). Group differences in accuracy, mean RT, and RT IIV were examined for both tasks. RESULTS: Individuals with mdaMCI had higher RT IIV than the other groups on both tasks. In RT IIV, we observed an interference control deficit in mdaMCI and sdaMCI relative to healthy controls, a finding not observed through accuracy or mean RT. DISCUSSION: RT IIV may detect subtle differences in inhibition deficits between aMCI subtypes that may not be evident with conventional behavioral measures. Findings support the supplementary use of RT IIV when assessing early executive function deficits.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desempeño Psicomotor / Tiempo de Reacción / Envejecimiento / Función Ejecutiva / Disfunción Cognitiva / Amnesia / Inhibición Psicológica Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Gerontol B Psychol Sci Soc Sci Asunto de la revista: CIENCIAS SOCIAIS / GERIATRIA / PSICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desempeño Psicomotor / Tiempo de Reacción / Envejecimiento / Función Ejecutiva / Disfunción Cognitiva / Amnesia / Inhibición Psicológica Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Gerontol B Psychol Sci Soc Sci Asunto de la revista: CIENCIAS SOCIAIS / GERIATRIA / PSICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos