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Prenatal Exposure to Mixtures of Persistent Endocrine-disrupting Chemicals and Birth Size in a Population-based Cohort of British Girls.
Marks, Kristin J; Howards, Penelope P; Smarr, Melissa M; Flanders, W Dana; Northstone, Kate; Daniel, Johnni H; Sjödin, Andreas; Calafat, Antonia M; Hartman, Terryl J.
Afiliación
  • Marks KJ; From the Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
  • Howards PP; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA.
  • Smarr MM; Oak Ridge Institute for Science and Education, Oak Ridge, TN.
  • Flanders WD; From the Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
  • Northstone K; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA.
  • Daniel JH; From the Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
  • Sjödin A; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA.
  • Calafat AM; Department of Population Health Sciences, Bristol Medical School, Oakfield House, Oakfield Grove, Bristol, United Kingdom.
  • Hartman TJ; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA.
Epidemiology ; 32(4): 573-582, 2021 07 01.
Article en En | MEDLINE | ID: mdl-33767116
BACKGROUND: Previous studies of endocrine-disrupting chemicals have examined one of these chemicals at a time in association with an outcome; studying mixtures better approximates human experience. We investigated the association of prenatal exposure to mixtures of persistent endocrine disruptors (perfluoroalkyl and polyfluoroalkyl substances [PFAS], polychlorinated biphenyls [PCBs], and organochlorine pesticides) with birth size among female offspring in the Avon Longitudinal Study of Parents and Children (ALSPAC), based in the United Kingdom in 1991-1992. METHODS: We quantified concentrations of 52 endocrine-disrupting chemicals in maternal serum collected during pregnancy at median 15-week gestation. Birth weight, crown-to-heel length, and head circumference were measured at birth; ponderal index and small for gestational age were calculated from these. We used repeated holdout Weighted Quantile Sum (WQS) regression and Bayesian kernel machine regression to examine mixtures in 313 mothers. RESULTS: Using WQS regression, all mixtures (each chemical class separately and all three together) were inversely associated with birth weight. A one-unit increase in WQS index (a one-decile increase in chemical concentrations) for all three classes combined was associated with 55 g (ß = -55 g, 95% confidence interval [CI] = -89, -22 g) lower birth weight. Associations were weaker but still inverse using Bayesian kernel machine regression. Under both methods, PFAS were the most important contributors to the association with birth weight. We also observed inverse associations for crown-to-heel length. CONCLUSIONS: These results are consistent with the hypothesis that prenatal exposure to mixtures of persistent endocrine-disrupting chemicals affects birth size.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Contaminantes Ambientales / Disruptores Endocrinos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Newborn / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Epidemiology Asunto de la revista: EPIDEMIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Contaminantes Ambientales / Disruptores Endocrinos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Newborn / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Epidemiology Asunto de la revista: EPIDEMIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos