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Lung virome: New potential biomarkers for asthma severity and exacerbation.
Choi, Sungmi; Sohn, Kyoung-Hee; Jung, Jae-Woo; Kang, Min-Gyu; Yang, Min-Suk; Kim, Sujeong; Choi, Jeong-Hee; Cho, Sang-Heon; Kang, Hye-Ryun; Yi, Hana.
Afiliación
  • Choi S; Institute for Biomaterials, Korea University, Seoul, Korea; Interdisciplinary Program in Precision Public Health, Korea University, Seoul, Korea.
  • Sohn KH; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.
  • Jung JW; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
  • Kang MG; Department of Internal Medicine, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea.
  • Yang MS; Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.
  • Kim S; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.
  • Choi JH; Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea; Allergy and Clinical Immunology Research Center, Hallym University College of Medicine, Chuncheon, Korea.
  • Cho SH; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
  • Kang HR; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea. Electronic address: helenmed@snu.ac.kr.
  • Yi H; Institute for Biomaterials, Korea University, Seoul, Korea; Interdisciplinary Program in Precision Public Health, Korea University, Seoul, Korea; School of Biosystems and Biomedical Sciences, Korea University, Seoul, Korea. Electronic address: hanayi@korea.ac.kr.
J Allergy Clin Immunol ; 148(4): 1007-1015.e9, 2021 10.
Article en En | MEDLINE | ID: mdl-33757721
BACKGROUND: Although some respiratory virus infections are known to contribute to the development and exacerbation of asthma, commensal viromes in airway have not been extensively studied due to technical challenges. OBJECTIVES: This study investigated the characteristics of the virome in asthmatic airways. METHODS: Both the bacteriome and virome profiles in sputum from 12 healthy individuals, 15 patients with nonsevere asthma, and 15 patients with severe asthma were analyzed and assessed for the association with clinical characteristics such as severity, exacerbation, Asthma Control Test (ACT), and lung function. RESULTS: While analysis of the 16S ribosomal RNA bacteriome in the airway showed no differences, clear contrasts in the diversity and composition of airway viromes were observed between healthy controls and patients with asthma. Herpesviruses were the most abundant type of virus in the asthma group (44.6 ± 4.6%), mainly with cytomegalovirus (CMV) and EBV accounting for 24.5 ± 3.3% and 16.9 ± 3.5%, respectively, in contrast to those in the healthy controls (5.4 ± 2.5% and 7.1 ± 3.0%, respectively). CMV and EBV were more abundant in patients with asthma who experienced exacerbation, and their abundance showed correlation with more severe asthma, lower ACT score, and lower lung function. On the contrary, bacteriophage that is abundant in healthy controls was severely reduced in patients with asthma in the order of nonsevere and severe asthma and presented significant positive correlation with ACT and FEV1/forced vital capacity. CONCLUSIONS: Lung viromes, especially, CMV, EBV, and bacteriophage may be potential biomarkers of asthma severity and exacerbation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Índice de Severidad de la Enfermedad / Viroma / Pulmón Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Allergy Clin Immunol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Índice de Severidad de la Enfermedad / Viroma / Pulmón Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Allergy Clin Immunol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos