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Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells.
Al-Fahdawi, Mohamed Qasim; Al-Doghachi, Faris A J; Abdullah, Qasim Khlaif; Hammad, Ruaa Tareq; Rasedee, Abdullah; Ibrahim, Wisam Nabeel; Alshwyeh, Hussah Abdullah; Alosaimi, Areej A; Aldosary, Sahar Khamees; Eid, Eltayeb E M; Rosli, Rozita; Taufiq-Yap, Y H; Al-Haj, Nagi A; Al-Qubaisi, Mothanna Sadiq.
Afiliación
  • Al-Fahdawi MQ; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
  • Al-Doghachi FAJ; Department of Chemistry, Faculty of Science, University of Basra 61004, Basra, Iraq.
  • Abdullah QK; DCH/Pediatric Department, Ramadi Teaching Hospital for Gynecology and Childhood, University of Anbar, Ramadi, Iraq.
  • Hammad RT; Department of Chemistry, Faculty of Science; University of Anbar, Ramadi, Iraq.
  • Rasedee A; Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. Electronic address: rasedee@upm.edu.my.
  • Ibrahim WN; Department of Biomedical Science, College of Health Sciences, QU health, Qatar University, Doha, Qatar; Biomedical and Pharmaceutical Research Unit, QU health, Qatar University, Doha, Qatar. Electronic address: w.ibrahim@qu.edu.qa.
  • Alshwyeh HA; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), Dammam 31441-1982, Saudi Arabia.
  • Alosaimi AA; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), Dammam 31441-1982, Saudi Arabia.
  • Aldosary SK; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), Dammam 31441-1982, Saudi Arabia.
  • Eid EEM; Department of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Saudi Arabia. Electronic address: eem.eid@qu.edu.sa.
  • Rosli R; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
  • Taufiq-Yap YH; Catalysis Science and Technology Research Centre, Faculty of Science; Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Faculty of Science and Natural Resources, Universiti Malaysia Sabah, 88300 Kota Kinabalu, Sabah, Malaysia.
  • Al-Haj NA; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Faculty of Medicine and Health Sciences, Sana'a University, Yemen.
  • Al-Qubaisi MS; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
Biomed Pharmacother ; 138: 111483, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33744756
The aim of this study was to prepare, characterize, and determine the in vitro anticancer effects of platinum-doped magnesia (Pt/MgO) nanoparticles. The chemical compositions, functional groups, and size of nanoparticles were determined using X-ray diffraction, Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, transmission electron microscopy, and scanning electron microscopy. Pt/MgO nanoparticles were cuboid and in the nanosize range of 30-50 nm. The cytotoxicity of Pt/MgO nanoparticles was determined via the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on the human lung and colonic cancer cells (A549 and HT29 respectively) and normal human lung and colonic fibroblasts cells (MRC-5 and CCD-18Co repectively). The Pt/MgO nanoparticles were relatively innocuous to normal cells. Pt/MgO nanoparticles downregulated Bcl-2 and upregulated Bax and p53 tumor suppressor proteins in the cancer cells. Pt/MgO nanoparticles also induced production of reactive oxygen species, decreased cellular glutathione level, and increased lipid peroxidation. Thus, the anticancer effects of Pt/MgO nanoparticles were attributed to the induction of oxidative stress and apoptosis. The study showed the potential of Pt/MgO nanoparticles as an anti-cancer compound.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Platino (Metal) / Estrés Oxidativo / Citotoxinas / Nanopartículas del Metal / Óxido de Magnesio Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2021 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Platino (Metal) / Estrés Oxidativo / Citotoxinas / Nanopartículas del Metal / Óxido de Magnesio Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2021 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Francia