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CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer.
Ahmed, Musaddeque; Soares, Fraser; Xia, Ji-Han; Yang, Yue; Li, Jing; Guo, Haiyang; Su, Peiran; Tian, Yijun; Lee, Hyung Joo; Wang, Miranda; Akhtar, Nayeema; Houlahan, Kathleen E; Bosch, Almudena; Zhou, Stanley; Mazrooei, Parisa; Hua, Junjie T; Chen, Sujun; Petricca, Jessica; Zeng, Yong; Davies, Alastair; Fraser, Michael; Quigley, David A; Feng, Felix Y; Boutros, Paul C; Lupien, Mathieu; Zoubeidi, Amina; Wang, Liang; Walsh, Martin J; Wang, Ting; Ren, Shancheng; Wei, Gong-Hong; He, Housheng Hansen.
Afiliación
  • Ahmed M; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Soares F; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Xia JH; Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland.
  • Yang Y; Changhai Hospital, Shanghai, China.
  • Li J; Changhai Hospital, Shanghai, China.
  • Guo H; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Su P; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Tian Y; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Lee HJ; Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Wang M; Department of Genetics, Washington University in St. Louis, St. Louis, MO, USA.
  • Akhtar N; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Houlahan KE; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Bosch A; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Zhou S; Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Mazrooei P; Vector Institute, Toronto, ON, Canada.
  • Hua JT; Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Chen S; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Petricca J; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Zeng Y; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Davies A; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Fraser M; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Quigley DA; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Feng FY; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Boutros PC; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Lupien M; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Zoubeidi A; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Wang L; Ontario Institute for Cancer Research, Toronto, ON, Canada.
  • Walsh MJ; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Wang T; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Ren S; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
  • Wei GH; The Vancouver Prostate Centre, Vancouver General Hospital and Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
  • He HH; Princess Margaret Cancer Center/University Health Network, Toronto, ON, Canada.
Nat Commun ; 12(1): 1781, 2021 03 19.
Article en En | MEDLINE | ID: mdl-33741908
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Metilación de ADN / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo / Sistemas CRISPR-Cas / Edición Génica Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Metilación de ADN / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo / Sistemas CRISPR-Cas / Edición Génica Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido