Your browser doesn't support javascript.
loading
Basal insulin requirement in patients with type 1 diabetes depends on the age and body mass index.
Mitsui, Yukari; Kuroda, Akio; Ishizu, Masashi; Mori, Hiroyasu; Kurahashi, Kiyoe; Kondo, Takeshi; Yoshida, Sumiko; Akehi, Yuko; Aihara, Ken-Ichi; Endo, Itsuro; Abe, Masahiro; Matsuhisa, Munehide.
Afiliación
  • Mitsui Y; Department of Hematology, Endocrinology and Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
  • Kuroda A; Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan.
  • Ishizu M; Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan.
  • Mori H; Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan.
  • Kurahashi K; Department of Hematology, Endocrinology and Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
  • Kondo T; Department of Endocrinology and Metabolism, Tokushima Red Cross Hospital, Komatsushima, Japan.
  • Yoshida S; Department of Hematology, Endocrinology and Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
  • Akehi Y; Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan.
  • Aihara KI; Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
  • Endo I; Department of Bioregulatory Sciences, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan.
  • Abe M; Department of Hematology, Endocrinology and Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
  • Matsuhisa M; Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan.
J Diabetes Investig ; 13(2): 292-298, 2022 Feb.
Article en En | MEDLINE | ID: mdl-33740836
AIMS/INTRODUCTION: To investigate the basal insulin requirement in patients with type 1 diabetes who are on multiple daily injections (MDI) and to assess the patient characteristics that affect the percent of total daily basal insulin dose to the total daily insulin dose (%TBD/TDD). MATERIALS AND METHODS: The subjects of this study were 67 inpatients with type 1 diabetes who were served diabetic meals of 25-30 kcal/kg standard body weight during several weeks of hospitalization. The basal insulin requirement was adjusted to keep the blood glucose level from bedtime to before breakfast within a 30 mg/dL difference. The bolus insulin dose before the meal was adjusted to keep the blood glucose level below 140 and 200 mg/dL before and 2 h after each meal, respectively. The total daily insulin dose (TDD), the percent of total daily basal insulin dose (TBD) to TDD (%TBD/TDD), and clinical characteristics were collected. RESULTS: The median (Q1, Q3) of TDD was 33.0 (26.0, 49.0) units, and the %TBD/TDD was 24.1 ± 9.8%. The %TBD/TDD was positively correlated with the body mass index (BMI) and negatively correlated with the age at the onset and at the examination according to a univariate analysis. However, the %TBD/TDD was dependent on the BMI (ß = 0.340, P = 0.004) and the age at examination (ß = -0.288, P = 0.012) according to the multiple regression analysis. CONCLUSIONS: The average %TBD/TDD in patients with type 1 diabetes on MDI was approximately 24% under inpatient conditions. The basal insulin requirement was dependent on the BMI and the age at examination.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 Límite: Humans Idioma: En Revista: J Diabetes Investig Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 Límite: Humans Idioma: En Revista: J Diabetes Investig Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón