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Social facilitation of long-lasting memory is mediated by CO2 in Drosophila.
Muria, Aurélie; Musso, Pierre-Yves; Durrieu, Matthias; Portugal, Felipe Ramon; Ronsin, Brice; Gordon, Michael D; Jeanson, Raphaël; Isabel, Guillaume.
Afiliación
  • Muria A; Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, Bat 4R4, 31062 Toulouse Cedex 9, France.
  • Musso PY; Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, Bat 4R4, 31062 Toulouse Cedex 9, France; Department of Zoology, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
  • Durrieu M; Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, Bat 4R4, 31062 Toulouse Cedex 9, France.
  • Portugal FR; Laboratoire Évolution et Diversité Biologique (EDB UMR 5174), Université de Toulouse, CNRS, IRD, 118 route de Narbonne, Bat 4R1, 31062 Toulouse Cedex 9, France; Ecole Nationale Supérieure Formation de l'Enseignement Agricole, Castanet-Tolosan, France.
  • Ronsin B; CBI, Université de Toulouse, CNRS, UPS, 118 route de Narbonne, Bat 4R4, 31062 Toulouse Cedex 9, France.
  • Gordon MD; Department of Zoology, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
  • Jeanson R; Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, Bat 4R4, 31062 Toulouse Cedex 9, France.
  • Isabel G; Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, Bat 4R4, 31062 Toulouse Cedex 9, France. Electronic address: guillaume.isabel@univ-tlse3.fr.
Curr Biol ; 31(10): 2065-2074.e5, 2021 05 24.
Article en En | MEDLINE | ID: mdl-33740428
How social interactions influence cognition is a fundamental question, yet rarely addressed at the neurobiological level. It is well established that the presence of conspecifics affects learning and memory performance, but the neural basis of this process has only recently begun to be investigated. In the fruit fly Drosophila melanogaster, the presence of other flies improves retrieval of a long-lasting olfactory memory. Here, we demonstrate that this is a composite memory composed of two distinct elements. One is an individual memory that depends on outputs from the α'ß' Kenyon cells (KCs) of the mushroom bodies (MBs), the memory center in the insect brain. The other is a group memory requiring output from the αß KCs, a distinct sub-part of the MBs. We show that social facilitation of memory increases with group size and is triggered by CO2 released by group members. Among the different known neurons carrying CO2 information in the brain, we establish that the bilateral ventral projection neuron (biVPN), which projects onto the MBs, is necessary for social facilitation. Moreover, we demonstrate that CO2-evoked memory engages a serotoninergic pathway involving the dorsal-paired medial (DPM) neurons, revealing a new role for this pair of serotonergic neurons. Overall, we identified both the sensorial cue and the neural circuit (biVPN>αß>DPM>αß) governing social facilitation of memory in flies. This study provides demonstration that being in a group recruits the expression of a cryptic memory and that variations in CO2 concentration can affect cognitive processes in insects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Facilitación Social / Dióxido de Carbono / Drosophila melanogaster / Memoria a Largo Plazo Límite: Animals Idioma: En Revista: Curr Biol Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Facilitación Social / Dióxido de Carbono / Drosophila melanogaster / Memoria a Largo Plazo Límite: Animals Idioma: En Revista: Curr Biol Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido