Bitter Taste Receptors (T2Rs) are Sentinels that Coordinate Metabolic and Immunological Defense Responses.

Harmon, Caroline P; Deng, Daiyong; Breslin, Paul A S

Harmon, Caroline P; Deng, Daiyong; Breslin, Paul A S.

Afiliación

Harmon CP; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
Deng D; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.
Breslin PAS; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.

Curr Opin Physiol ; 20: 70-76, 2021 Apr.

Article en En | MEDLINE | ID: mdl-33738371

RESUMEN

In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irritants. This review will provide an overview of T2R-regulated processes throughout the body that function defensively. We propose a broader definition of T2Rs as chemosensory sentinels that monitor toxic, metabolic, and infectious threats and initiate defensive responses.

Palabras clave

T2Rs; bitter taste; endocrine; homeostasis; hormones; immune; immunobiology; metabolism; regulatory physiology; sentinels

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Opin Physiol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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