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Mapping default mode connectivity alterations following a single season of subconcussive impact exposure in youth football.
DeSimone, Jesse C; Davenport, Elizabeth M; Urban, Jillian; Xi, Yin; Holcomb, James M; Kelley, Mireille E; Whitlow, Christopher T; Powers, Alexander K; Stitzel, Joel D; Maldjian, Joseph A.
Afiliación
  • DeSimone JC; Advanced Neuroscience Imaging Research (ANSIR) Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Davenport EM; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Urban J; Advanced Neuroscience Imaging Research (ANSIR) Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Xi Y; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Holcomb JM; Department of Biomedical Engineering, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
  • Kelley ME; Virginia Tech - Wake Forest School of Biomedical Engineering, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
  • Whitlow CT; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Powers AK; Advanced Neuroscience Imaging Research (ANSIR) Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Stitzel JD; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Maldjian JA; Department of Biomedical Engineering, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Hum Brain Mapp ; 42(8): 2529-2545, 2021 06 01.
Article en En | MEDLINE | ID: mdl-33734521
Repetitive head impact (RHI) exposure in collision sports may contribute to adverse neurological outcomes in former players. In contrast to a concussion, or mild traumatic brain injury, "subconcussive" RHIs represent a more frequent and asymptomatic form of exposure. The neural network-level signatures characterizing subconcussive RHIs in youth collision-sport cohorts such as American Football are not known. Here, we used resting-state functional MRI to examine default mode network (DMN) functional connectivity (FC) following a single football season in youth players (n = 50, ages 8-14) without concussion. Football players demonstrated reduced FC across widespread DMN regions compared with non-collision sport controls at postseason but not preseason. In a subsample from the original cohort (n = 17), players revealed a negative change in FC between preseason and postseason and a positive and compensatory change in FC during the offseason across the majority of DMN regions. Lastly, significant FC changes, including between preseason and postseason and between in- and off-season, were specific to players at the upper end of the head impact frequency distribution. These findings represent initial evidence of network-level FC abnormalities following repetitive, non-concussive RHIs in youth football. Furthermore, the number of subconcussive RHIs proved to be a key factor influencing DMN FC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos en Atletas / Conmoción Encefálica / Corteza Cerebral / Conectoma / Red en Modo Predeterminado Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos en Atletas / Conmoción Encefálica / Corteza Cerebral / Conectoma / Red en Modo Predeterminado Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos