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Effects of deep inspiration breath hold on prone photon or proton irradiation of breast and regional lymph nodes.
Speleers, Bruno; Schoepen, Max; Belosi, Francesca; Vakaet, Vincent; De Neve, Wilfried; Deseyne, Pieter; Paelinck, Leen; Vercauteren, Tom; Parkes, Michael J; Lomax, Tony; Van Greveling, Annick; Bolsi, Alessandra; Weber, Damien C; Veldeman, Liv; De Gersem, Werner.
Afiliación
  • Speleers B; Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Radiotherapiepark, Corneel Heymanslaan 10, 9000, Ghent, Belgium. Bruno.speleers@ugent.be.
  • Schoepen M; Department of Industrial Systems Engineering and Product Design, Faculty of Engineering and Architecture, Ghent University, Ghent, Belgium.
  • Belosi F; Paul Scherrer Institut, Villigen, Switzerland.
  • Vakaet V; Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Radiotherapiepark, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
  • De Neve W; Department of Radiation Oncology, University Hospital Ghent, Ghent, Belgium.
  • Deseyne P; Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Radiotherapiepark, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
  • Paelinck L; Department of Radiation Oncology, University Hospital Ghent, Ghent, Belgium.
  • Vercauteren T; Department of Radiation Oncology, University Hospital Ghent, Ghent, Belgium.
  • Parkes MJ; Department of Radiation Oncology, University Hospital Ghent, Ghent, Belgium.
  • Lomax T; Academic Medical Centre (AMC), University of Amsterdam, Amsterdam, the Netherlands.
  • Van Greveling A; Paul Scherrer Institut, Villigen, Switzerland.
  • Bolsi A; Department of Radiation Oncology, University Hospital Ghent, Ghent, Belgium.
  • Weber DC; Paul Scherrer Institut, Villigen, Switzerland.
  • Veldeman L; Paul Scherrer Institut, Villigen, Switzerland.
  • De Gersem W; Radiation Oncology Department, University Hospital of Bern, Bern, Switzerland.
Sci Rep ; 11(1): 6085, 2021 03 16.
Article en En | MEDLINE | ID: mdl-33727599
We report on a comparative dosimetrical study between deep inspiration breath hold (DIBH) and shallow breathing (SB) in prone crawl position for photon and proton radiotherapy of whole breast (WB) and locoregional lymph node regions, including the internal mammary chain (LN_MI). We investigate the dosimetrical effects of DIBH in prone crawl position on organs-at-risk for both photon and proton plans. For each modality, we further estimate the effects of lung and heart doses on the mortality risks of different risk profiles of patients. Thirty-one patients with invasive carcinoma of the left breast and pathologically confirmed positive lymph node status were included in this study. DIBH significantly decreased dose to heart for photon and proton radiotherapy. DIBH also decreased lung doses for photons, while increased lung doses were observed using protons because the retracting heart is displaced by low-density lung tissue. For other organs-at-risk, DIBH resulted in significant dose reductions using photons while minor differences in dose deposition between DIBH and SB were observed using protons. In patients with high risks for cardiac and lung cancer mortality, average thirty-year mortality rates from radiotherapy-related cardiac injury and lung cancer were estimated at 3.12% (photon DIBH), 4.03% (photon SB), 1.80% (proton DIBH) and 1.66% (proton SB). The radiation-related mortality risk could not outweigh the ~ 8% disease-specific survival benefit of WB + LN_MI radiotherapy in any of the assessed treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mama / Contencion de la Respiración / Neoplasias de Mama Unilaterales / Ganglios Linfáticos Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mama / Contencion de la Respiración / Neoplasias de Mama Unilaterales / Ganglios Linfáticos Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido